Diseases of the genitourinary system

Schoenlein-Genoch disease and kidney damage

Henoch-Schonlein purpura disease is a systemic vasculitis that primarily affects small vessels with the deposition of immune complexes containing IgA in their walls, and is manifested by skin lesions in combination with lesions of the gastrointestinal tract, kidney glomeruli and joints.

Microscopic polyangiitis

Microscopic polyangiitis is a necrotizing vasculitis with minimal or no immune deposits, affecting small vessels (arterioles, capillaries, venules), less often medium-caliber arteries, with necrotizing glomerulonephritis and pulmonary capillaritis predominating in the clinical picture.

Treatment of kidney damage in Wegener's granulomatosis

Since the prognosis depends on the timing of the initiation of treatment for Wegener's granulomatosis, the main principle of therapy is its early initiation, even if there are no morphological and serological data.

Diagnosis of renal damage in Wegener's granulomatosis

In patients with Wegener's granulomatosis, a number of nonspecific laboratory changes are noted: increased ESR, neutrophilic leukocytosis, thrombocytosis, normochromic anemia, and in a small percentage of cases, eosinophilia.

Symptoms of kidney damage in Wegener's granulomatosis

The onset of Wegener's granulomatosis often occurs as a flu-like syndrome, the development of which is associated with the circulation of proinflammatory cytokines, possibly produced as a result of a bacterial or viral infection preceding the prodromal period of the disease.

Causes and pathogenesis of renal damage in Wegener's granulomatosis

The exact cause of Wegener's granulomatosis has not been established. It is assumed that there is a connection between the development of Wegener's granulomatosis and infection, indirectly confirmed by the facts of frequent onset and exacerbation of the disease in the winter-spring period, mainly after respiratory infections, which is associated with the entry of an antigen (possibly of viral or bacterial origin) through the respiratory tract.

Wegener's granulomatosis and kidney damage

Wegener's granulomatosis is a granulomatous inflammation of the respiratory tract with necrotizing vasculitis of small and medium-sized vessels, combined with necrotizing glomerulonephritis.

Treatment of kidney damage in periarteritis nodosa

The choice of therapeutic regimen and drug doses is determined by clinical and laboratory signs of disease activity (fever, weight loss, dysproteinemia, increased ESR), the severity and rate of progression of damage to internal organs (kidneys, nervous system, gastrointestinal tract), the severity of arterial hypertension, and the presence of active HBV replication.

Diagnosis of kidney damage in periarteritis nodosa

Diagnosis of generalized polyarteritis nodosa does not cause difficulties at the height of the disease, when there is a combination of kidney damage with high arterial hypertension and disorders of the gastrointestinal tract, heart, and peripheral nervous system.

Pathogenesis of renal damage in periarteritis nodosa

Polyarteritis nodosa is characterized by the development of segmental necrotizing vasculitis of medium and small caliber arteries. The features of vascular damage are considered to be the frequent involvement of all three layers of the vessel wall (panvasculitis)