Diseases of the genitourinary system

Antiphospholipid syndrome and kidney damage - Treatment

Treatment of nephropathy associated with antiphospholipid syndrome is not clearly defined, since there are currently no large controlled comparative studies assessing the effectiveness of different treatment regimens for this pathology.

Antiphospholipid syndrome and kidney damage - Diagnosis

Characteristic features of antiphospholipid syndrome are thrombocytopenia, usually moderate (platelet count is 100,000-50,000 in 1 μl) and not accompanied by hemorrhagic complications, and Coombs-positive hemolytic anemia.

Antiphospholipid syndrome - Causes and pathogenesis

The causes of antiphospholipid syndrome are unknown. Most often, antiphospholipid syndrome develops in rheumatic and autoimmune diseases, mainly in systemic lupus erythematosus.

Antiphospholipid syndrome and kidney damage - Symptoms

The symptoms of antiphospholipid syndrome are quite varied. The polymorphism of symptoms is determined by the localization of thrombi in veins, arteries or small intraorgan vessels. As a rule, thromboses recur either in the venous or arterial bed.

Antiphospholipid syndrome and kidney damage

Antiphospholipid syndrome (APS) is a clinical and laboratory symptom complex associated with the synthesis of antibodies to phospholipids (aPL) and characterized by venous and/or arterial thrombosis, habitual miscarriage, and thrombocytopenia.

Thrombotic microangiopathy - Treatment

Treatment of thrombotic microangiopathy includes the use of fresh frozen plasma, the purpose of which is to prevent or limit intravascular thrombus formation and tissue damage, and supportive therapy aimed at eliminating or limiting the severity of the main clinical manifestations.

Thrombotic microangiopathy - Diagnosis

Diagnosis of thrombotic microangiopathy consists of identifying the main markers of this disease - hemolytic anemia and thrombocytopenia.

Thrombotic microangiopathy - Symptoms

Typical postdiarrheal hemolytic uremic syndrome is preceded by a prodrome, which manifests itself in most patients with bloody diarrhea lasting from 1 to 14 days (on average 7 days).

Thrombotic microangiopathy - Causes and pathogenesis

The causes of thrombotic microangiopathy are varied. There are infectious forms of hemolytic uremic syndrome and those not associated with infection, sporadic ones.

Thrombotic microangiopathy and renal damage

The term "thrombotic microangiopathy" defines a clinical and morphological syndrome manifested by microangiopathic hemolytic anemia and thrombocytopenia, which develops as a result of occlusion of blood vessels of the microcirculatory bed (arterioles, capillaries) of various organs, including the kidneys, by thrombi containing aggregated platelets and fibrin.