Diseases of the genitourinary system

Scleroderma and kidney damage - Diagnosis

Laboratory examination of patients with systemic scleroderma may reveal anemia, moderate increase in ESR, leukocytosis or leukopenia, hyperproteinemia with hypergammaglobulinemia, elevated levels of C-reactive protein and fibrinogen.

Scleroderma and kidney damage - Treatment

Treatment of systemic scleroderma currently involves the use of three main groups of drugs: antifibrotic; anti-inflammatory and immunosuppressant; vascular agents.

Scleroderma and kidney damage - Symptoms

There are several subtypes (clinical forms) of systemic scleroderma. Depending on the prevalence and severity of skin changes, two main forms are distinguished - diffuse and limited.

Scleroderma and kidney damage - Causes

The causes of scleroderma have not been sufficiently studied. Currently, environmental factors are considered to play a significant role in the development of the disease. Unfavorable exogenous and endogenous influences (infections, cooling, medications, industrial and household chemical agents, vibration, stress, endocrine disorders) apparently play a triggering role in the development of the disease in individuals with a genetic predisposition.

Scleroderma and kidney damage

Systemic scleroderma is a polysyndromic autoimmune disease characterized by progressive fibrosis and widespread vascular pathology such as obliterating microangiopathy, which underlie generalized Raynaud's syndrome, skin lesions, and internal organs (lungs, heart, gastrointestinal tract, kidneys).

Goodpasture's syndrome and kidney damage

Goodpasture's syndrome, caused by the presence of specific antibodies to the basement membrane of glomerular capillaries and/or alveoli, is manifested by pulmonary hemorrhages and rapidly progressive glomerulonephritis.

Mixed cryoglobulinemia and kidney damage

Mixed cryoglobulinemia is a special type of systemic small vessel vasculitis characterized by the deposition of cryoglobulins in the vessel wall and most often manifested by skin lesions in the form of purpura and renal glomeruli.

Schoenlein-Genoch disease - Diagnosis

Laboratory diagnostics of Henoch-Schonlein disease does not reveal any specific tests. Most patients with high activity of vasculitis have an increase in ESR. In children, in 30% of cases, an increase in antistreptolysin-O titers, rheumatoid factor, and an increase in C-reactive protein are detected.

Schoenlein-Genoch disease - Symptoms.

Hemorrhagic vasculitis (Schonlein-Henoch disease) is in most cases a benign disease, prone to spontaneous remission or healing within a few weeks from the moment of onset.

Schoenlein-Genoch disease - Causes and pathogenesis

The development of Schonlein-Tenoch purpura is associated with infections, food allergies, drug intolerance, and alcohol consumption. In most cases, the disease is preceded by a nasopharyngeal or intestinal infection. The development of hemorrhagic vasculitis is associated with a number of bacteria and viruses.