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Diseases of the genitourinary system

Tubulointerstitial nephropathies

Tubulointerstitial nephropathy includes various kidney diseases that occur with primary damage mainly to the structures of the tubules and interstitium.

Bartter's syndrome

Bartter syndrome is a genetically determined tubular dysfunction characterized by hypokalemia, metabolic alkalosis, hyperuricemia, and increased renin and aldosterone activity.

Renal tubular acidosis.

Renal tubular acidosis is metabolic, the SCF is usually unchanged. Proximal renal tubular acidosis is formed when the ability of epithelial cells to reabsorb bicarbonates is reduced. Isolated or within the Fanconi syndrome (primary and secondary) proximal renal tubular acidosis is observed.

Aminoaciduria and cystinuria

Aminoaciduria (aminoaciduria) is an increase in the excretion of amino acids in the urine or the presence in the urine of amino acid products that are not normally contained in it (for example, ketone bodies).

Glucosuria

Glucosuria is an increase in the excretion of glucose in the urine. Renal glucosuria is often an independent disease; it is usually discovered by chance; polyuria and polydipsia are observed extremely rarely. Sometimes renal glucosuria is accompanied by other tubulopathies, including those in Fanconi syndrome.

Canalicular dysfunction

Nephropathy, characterized mainly by a violation of transport processes, as a rule, with preserved filtration function of the kidneys, tubular dysfunctions.

Amyloidosis and kidney damage - Treatment

In addition to the main therapeutic regimens, treatment of amyloidosis should include symptomatic methods aimed at reducing the severity of congestive circulatory failure, arrhythmias, edema syndrome, and correction of arterial hypotension or hypertension.

Amyloidosis and kidney damage - Diagnosis

In secondary AA amyloidosis, 80% of patients seek medical attention during the onset of nephrotic syndrome of varying severity.

Amyloidosis and kidney damage - Causes and pathogenesis

The basis of tissue amyloid deposits are amyloid fibrils - special protein structures with a diameter of 5-10 nm and a length of up to 800 nm, consisting of 2 or more parallel filaments.

Amyloidosis and kidney damage

Amyloidosis is a group concept that unites diseases that are characterized by extracellular deposition of a specific insoluble fibrillar protein, amyloid.