Diseases of children (pediatrics)

Cerge-Strauss syndrome

Granulomatous inflammatory angiitis - Churg-Strauss syndrome belongs to a group of systemic vasculitis with damage to small-caliber vessels (capillaries, venules, arterioles), associated with the detection of antineutrophil cytoplasmic autoantibodies (ANCA). In children, this form of systemic vasculitis is rare.

How is Takayasu's disease treated?

In the acute phase, medium doses of prednisolone (1 mg/kg per day with a dose reduction after 1-2 months to a maintenance dose) and methotrexate (at least 10 mg/m21 times per week) are prescribed. The maximum dose of prednisolone is given until the disappearance of clinical and laboratory signs of process activity, after which it is slowly reduced to a maintenance dose (10-15 mg/day).

Diagnosis of Takayasu's disease

The diagnosis of nonspecific aortoarteritis is established on the basis of typical clinical signs and instrumental research data.

Symptoms of Takayasu's disease

Non-specific aortoarteritis is characterized by general inflammatory manifestations and a combination of various syndromes: peripheral blood flow insufficiency, cardiovascular, cerebrovascular, abdominal, pulmonary, arterial hypertension. The classic sign of the disease is the syndrome of asymmetry or absence of pulse.

What causes Takayasu's disease?

The cause of Takayasu's disease is unknown. Possible causes include infection (particularly tuberculosis), viruses, drug and serum intolerance. There is evidence of a genetic predisposition to non-specific aortoarteritis, as illustrated by the development of the disease in identical twins and the association with HLA Bw52, Dwl2, DR2 and DQw (in the Japanese population).

Nonspecific aortoarteritis (Takayasu's disease)

Non-specific aortoarteritis (aortic arch syndrome, Takayasu disease, pulseless disease) is a destructive-productive segmental aortitis and subaortic panarteritis of arteries rich in elastic fibers with possible damage to their coronary and pulmonary branches.

Mucocutaneous lymphonodular syndrome (Kawasaki syndrome): causes, symptoms, diagnosis, treatment

Mucocutaneous lymphonodular syndrome (acute infantile febrile cutaneous-mucosal-glandular syndrome, Kawasaki disease, Kawasaki syndrome) is an acute systemic disease characterized by morphologically predominant lesions of medium and small arteries with the development of destructive-proliferative vasculitis identical to nodular polyarteritis, and clinically by fever, changes in the mucous membranes, skin, lymph nodes, and possible lesions of the coronary and other visceral arteries.