Diseases of the immune system (immunology)

Allergic diseases and other hypersensitivity reactions: causes, symptoms, diagnosis, treatment

Allergic diseases and other hypersensitivity reactions are the result of an inadequate, excessively expressed immune response that does not correspond to the severity of the disease or infectious process.

ZAP-70 insufficiency: causes, symptoms, diagnosis, treatment

ZAP-70 (zeta-a-associated protein-70) deficiency results in impaired T-lymphocyte activation, which causes defects in signaling systems.

X-linked lymphoproliferative syndrome (Duncan syndrome): causes, symptoms, diagnosis, treatment

X-linked lymphoproliferative syndrome results from a defect in T-lymphocytes and natural killer cells and is characterized by an abnormal response to Epstein-Barr virus infections, leading to liver damage, immunodeficiency, lymphoma, fatal lymphoproliferative disease, or bone marrow aplasia.

X-linked agammaglobulinemia (Bruton's disease)

X-linked agammaglobulinemia is a disease that is accompanied by the development of low levels of immunoglobulins or their absence, which often leads to the development of recurrent infections.

Wiskott-Aldrich syndrome: causes, symptoms, diagnosis, treatment

Wiskott-Aldrich syndrome is characterized by impaired cooperation between B and T lymphocytes and is characterized by recurrent infections, atopic dermatitis, and thrombocytopenia.

Transient hypogammaglobulinemia of early age: causes, symptoms, diagnosis, treatment

Transient hypogammaglobulinemia of infancy is a temporary decrease in serum IgG and sometimes IgA and other Ig isotypes to levels below age norms.

Severe combined immunodeficiency: causes, symptoms, diagnosis, treatment

Severe combined immunodeficiency is characterized by the absence of T cells and low, high, or normal numbers of B cells and natural killer cells. Most infants develop opportunistic infections within 1 to 3 months of life.

Leukocyte adhesion insufficiency: causes, symptoms, diagnosis, treatment

Leukocyte adhesion deficiency is a consequence of a defect in adhesion molecules, which leads to dysfunction of granulocytes and lymphocytes and the development of recurrent soft tissue infections.

Hyperimmunoglobulinemia IgM syndrome

IgM hyperimmunoglobulinemia syndrome is associated with immunoglobulin deficiency and is characterized by normal or elevated serum IgM levels and absent or decreased levels of other serum immunoglobulins, resulting in increased susceptibility to bacterial infections.

IgE hyperimmunoglobulinemia syndrome: causes, symptoms, diagnosis, treatment

IgE hyperimmunoglobulinemia syndrome combines T- and B-cell deficiency and is characterized by recurrent staphylococcal abscesses of the skin, lungs, joints, and internal organs, beginning in early childhood.