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Transient hypogammaglobulinemia of early age: causes, symptoms, diagnosis, treatment
Medical expert of the article
Last reviewed: 20.11.2021
Transient hypogammaglobulinemia of early age is a temporary decrease in serum IgG and sometimes IgA and other isotypes of Ig to a level below the age norms.
Transient hypogammaglobulinemia of early age is characterized by continuing decrease in IgG level after physiological destruction of maternal IgG at the age of about 3-6 months. This condition rarely leads to severe infections and is not a true immunodeficiency. The diagnosis is based on measuring the level of serum immunoglobulins and revealing the fact that in response to the vaccine antigen (eg, tetanus, diphtheria), normal production of antibodies occurs. However, this condition should be differentiated with permanent forms of hypogammaglobulinemia, in which specific antibodies to vaccine antigens are not produced. In the introduction of IVIG there is no need; This state can last from several months to several years and usually passes independently.