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Transient hypogammaglobulinemia of early age: causes, symptoms, diagnosis, treatment
Medical expert of the article
Last reviewed: 07.07.2025
Transient hypogammaglobulinemia of infancy is a temporary decrease in serum IgG and sometimes IgA and other Ig isotypes to levels below age norms.
Transient hypogammaglobulinemia of infancy is characterized by a continuing decline in IgG levels after the physiological destruction of maternal IgG at approximately 3 to 6 months of age. This condition rarely leads to severe infections and is not a true immunodeficiency. Diagnosis is based on measurement of serum immunoglobulins and demonstration that normal antibody production occurs in response to a vaccine antigen (eg, tetanus, diphtheria). However, this condition must be differentiated from permanent forms of hypogammaglobulinemia, in which specific antibodies to vaccine antigens are not produced. IVIG is not necessary; the condition may persist for months to years and is usually self-limited.