Chronic granulomatous disease is characterized by the inability of leukocytes to produce active forms of oxygen and the inability to phagocytose microorganisms.
Chediak-Higashi syndrome is characterized by impaired lysis of phagocytosed bacteria, resulting in the development of recurrent bacterial respiratory and other infections, albinism of the skin and eyes are also noted.
Ataxia-telangiectasia is characterized by a violation of T-cell immunity, progressive cerebral ataxia, conjunctival and skin telangiectasias and skin and recurrent infections of the paranasal and lung.