Common variable immunodeficiency (acquired hypogammaglobulinemia or late-onset hypogammaglobulinemia) is characterized by low Ig levels with phenotypically normal B lymphocytes that are capable of proliferation but do not complete their development by forming Ig-producing cells.
Chronic granulomatous disease is characterized by the inability of leukocytes to produce reactive oxygen species and the inability to phagocytize microorganisms.
Chediak-Higashi syndrome is characterized by impaired lysis of phagocytized bacteria, resulting in recurrent bacterial respiratory and other infections, and albinism of the skin and eyes.
Ataxia-telangiectasia is characterized by impaired T-cell immunity, progressive cerebral ataxia, conjunctival and cutaneous telangiectasias, and recurrent sinus and lung infections.
