Infectious and parasitic diseases

Astrakhan rickettsiosis fever: causes, symptoms, diagnosis, treatment

Astrakhan rickettsial fever (synonyms: Astrakhan spotted fever, Astrakhan fever, Astrakhan tick-borne spotted fever) is a rickettsiosis from the group of spotted fevers, transmitted by the tick Rhipicephalus pumilio and characterized by a benign course, the presence of a primary affect, fever, and a maculopapular rash.

Marseille fever: causes, symptoms, diagnosis, treatment

Marseilles fever (Marseilles febris, ixodorickettsiosis, Marseilles rickettsiosis, papular fever, Carducci-Olmer disease, tick-borne fever, Mediterranean fever, etc.) is an acute zoonotic rickettsiosis with a transmissible mechanism of transmission of the pathogen, characterized by a benign course, the presence of a primary affect and a widespread maculopapular rash.

Endemic rat typhus: causes, symptoms, diagnosis, treatment

Endemic typhus is a sporadic acute benign zoonotic rickettsiosis transmitted through ectoparasites of mice and rats, with a characteristic cyclical course, fever, moderate intoxication and widespread roseolous-papular rash.

Brill's disease (Brill-Zinsser disease): causes, symptoms, diagnosis, treatment

Brill's disease (Brill-Zinsser, relapsing typhus) is an acute cyclic infectious disease, which is an endogenous relapse of typhus, which manifests itself many years later in people who have had epidemic typhus. This disease is characterized by sporadicity, absence of pediculosis, typical clinical symptoms, and a milder course than epidemic typhus.

Typhus - Treatment and Prevention

All patients with suspected typhus should be hospitalized in an infectious diseases hospital (department). They are prescribed strict bed rest until the 5th-6th day of normalization of body temperature. Then the patients are allowed to sit up, and from the 8th day they can walk around the ward, first under the supervision of a nurse, and then independently. Patients must constantly monitor blood pressure.

Typhus - Diagnosis

The diagnosis of typhus is established on the basis of clinical and epidemiological data and confirmed by laboratory tests. Of significant importance are the presence of pediculosis, the characteristic appearance of the patient, intense headache combined with insomnia, the appearance of a rash on the 5th day of illness, damage to the central nervous system, and hepatosplenic syndrome.

Typhus - Symptoms

Epidemic typhus has an incubation period that lasts from 5 to 25, more often 10-14 days. Epidemic typhus proceeds cyclically: the initial period is the first 4-5 days (from the rise in temperature to the appearance of a rash); the peak period is 4-8 days (from the appearance of a rash to the end of the feverish state); the recovery period is from the day the temperature returns to normal until all symptoms of epidemic typhus disappear.

Typhus - What's going on?

The pathomorphological basis of typhus is generalized destructive-proliferative endovasculitis, which includes three components: thrombus formation; destruction of the vascular wall; cellular proliferation.

Typhus - Causes

The cause of typhus is Rickettsia prowazekii, a polymorphic gram-negative microorganism ranging in size from 0.5 to 1 µm, an obligate intracellular parasite.

Epidemic typhus

Epidemic typhus (European, classical, louse-borne typhus; jail fever) is caused by Rickettsia prowazekii. Symptoms of epidemic typhus are prolonged and include high fever, intractable headache, and a maculopapular rash.