For the first time in 1951, E. J. Gardner, and 2 years later E. J. Gardner and R. C. Richards described a unique disease characterized by multiple skin and subcutaneous lesions that occur simultaneously with tumor lesions of the bones and tumors of the soft tissues. At present, this disease, which combines polyposis of the gastrointestinal tract, multiple osteomas and osteofibromas, tumors of the soft tissues, is called Gardner's syndrome.