Review and facts about osteoarthritis

Osteoarthritis, arterial hypertension and obesity: the problem of comorbidity

In patients with osteoarthritis (OA), in combination with the metabolic syndrome (MS), significant lipid metabolism disorders were detected, an increase in oxidative stress activity, which contributed to the degradation of the connective tissue structures of the body.

Osteoarthritis: What should the patient know?

Human joints are wonderful anatomical formations. What man-made machine can exist and work for dozens and dozens of years? To better appreciate the work of such a wonderful device, as joints, consider the following facts. If the body weight of a person is 50 kg, with each step on his knee joint, the load is more than 150 kg.

Osteoarthritis and osteoporosis

There are a number of common factors predisposing to the development of both osteoarthritis and osteoporosis - female gender, old age, genetic predisposition (familial aggregation of collagen type I gene, etc.), estrogen deficiency and vitamin D, etc.

Repair of articular cartilage and growth factors in the pathogenesis of osteoarthritis

Thanks to the progress of biotechnology, in particular cloning technology, recently a growing list of growth factors, which, being anabolic factors, play an important but not completely understandable role in the pathogenesis of osteoarthritis.

Effect of exercise on osteoarthritis

The popularity of jogging among the population of many countries in the world has recently attracted attention to running for long distances as a factor in the risk of developing osteoarthritis.

Osteoarthrosis: Influence of meniscectomy on articular cartilage

Menisci are structures that increase the congruence of articular surfaces of the femoral and tibia, increase lateral stability and improve the distribution of synovial fluid, as well as the exchange of nutrients with articular cartilage

Genetic and metabolic aspects of the pathogenesis of osteoarthritis

In 1803 W. Heberden described "slightly dense knots, the size of a small pea" on the back surface of the distal interphalangeal joints of the hands. This feature, according to the author, distinguishes osteoarthritis from other joint diseases, including gout.

The role of enzymes and cytokines in the pathogenesis of osteoarthritis

In recent years, a great deal of research has focused on the identification of proteases responsible for the degradation of ECM of articular cartilage in osteoarthritis.

The role of changes in the subchondral bone in the pathogenesis of osteoarthritis

Along with the degeneration of articular cartilage, the pathological process in osteoarthritis involves the underlying bone tissue. It is suggested that the thickening of the subchondral plate promotes the progression of osteoarthritis.

Role of crystal deposition in the pathogenesis of osteoarthritis

Natural cytokine inhibitors can directly inhibit the binding of cytokines to the receptors of cell membranes, reducing their pro-inflammatory activity. Natural inhibitors of cytokines can be divided into three classes according to their mode of action.

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