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Research of hemostasis system

Factor XII (Hagemann)

Factor XII (Hagemann) is a sialoglycoprotein activated by collagen, contact with a foreign surface, adrenaline and a number of proteolytic enzymes (in particular, plasmin). Factor XII initiates intravascular coagulation, in addition, factor XIIa transforms prekallikrein plasma into kallikreins. Active factor XII serves as an activator of fibrinolysis.

Activated partial thromboplastin time (APTT)

Activated partial thromboplastin time (APTT) is one of the most valuable common tests to obtain an idea of the blood coagulation system. APTTV is a test that detects exclusively plasma defects of the internal X-factor activation system in phase I (formation of prothrombinase) of blood coagulation.

Aggregation of platelets with ADP

The processes of platelet aggregation are studied using an aggregometer that reflects the course of aggregation graphically in the form of a curve; ADP is used as an aggregation stimulator. Before the addition of a proagregant (ADP), random oscillations of the optical density curve are possible. After the addition of the aggregate, oscillations appear on the curve due to a change in the form of the platelets.

Hemostasis

The system of hemostasis is a set of functional-morphological and biochemical mechanisms ensuring the preservation of the liquid state of the blood, preventing and stopping bleeding, and the integrity of the blood vessels.

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