Drugs used to regulate delivery

Medicines used to regulate childbirth have a multi-purpose purpose. In obstetric practice, most often use pain medication, a means to stimulate the contractile function of the uterus or, conversely, to suppress it.

Medications also include anticonvulsants, preparations for women in labor with high blood pressure, cardiac, cerebral, nephrologic disorders. And in the presence of chronic inflammatory diseases can not do without antimicrobial and antibacterial drugs.

Central and peripheral anticholinergics (antispasmodics)

Excitation of muscular cholinergic receptors of myometrium causes an increase in hydrolysis of phosphoinositides, activation of phospholipase A2, activation of protein kinase C, reduction.

Dopaminergic drugs

Levodopa. Dioxyphenylalanine (DOPA or DOPA) is a biogenic substance formed in the body from tyrosine and is a precursor of dopamine, which in turn is converted into noradrenaline and then into adrenaline.

Beta-blockers and childbirth

Anaprilin (propranolol, obzidan, inderal). Anaprilin is a specific beta-blocker. The drug is well absorbed in the gastrointestinal tract, in connection with which it is quite suitable for oral administration. The optimal dose (the concentration of anaprilin in the blood after taking the drug inside is determined in the interval from 45 to 120 min.

Antiadrenergic drugs

Clopheline (hemiton, catapresane, clonidine) - has a pronounced hypotensive effect. Clopheline is used in therapeutic practice for the treatment of hypertension. It was found that with late toxemia of pregnant women, the level of catecholamines in the blood increases, and the use of clonidine leads to hypotensive, sedative and small diuretic effects.

N-anticholinergics

Gangleron. The drug has ganglioblokiruyuschim, central holinoliticheskim, spasmolytic and anesthetic action. Gangleron is a persistent substance that slowly hydrolyzes in the body. It dilates the vessels, causing an antihypertensive effect.

Spazmoanalgetik perfection

Theoretically, any substance that in a proportionate dose weakens the spasm of smooth muscles caused by acetylcholine can be used as an antispasmodic. In practice, far from all anticholinergic substances are used as antispasmodics.

Analgesics

Promedol (trimeperidine hydrochloride). Promedol, as is known, is a synthetic substitute for morphine and has a pronounced analgesic effect. Reduction of pain sensitivity under the influence of promedol develops after subcutaneous injection after 10-15 minutes.

Muscle relaxants of central and peripheral action

In recent years, in clinical practice, widespread use of muscle relaxants of central action. Due to the fact that, in contrast to peripheral action relaxants, they do not disable spontaneous breathing, nor do they adversely affect the cardiovascular system and other vital organs and systems.

Tranquilizers at delivery

From the troupe of small tranquilizers use trioxazine, nosepam, phenazepam, sibazone (seduxen, diaeepam), etc. Trioxazine. Has a moderate tranquilizing effect, combined with activation, a certain increase in mood without drowsiness and intellectual retardation, does not have a muscle relaxant effect.

Prostaglandins

Since 1970, natural prostaglandins have been used as therapeutic agents in obstetric and gynecological practice for the maturation of the cervix and premature termination of pregnancy, with the aim of induction and rhodostimulation.

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