Drugs used to regulate delivery

Medicines used to regulate childbirth have a multi-purpose purpose. In obstetric practice, most often use pain medication, a means to stimulate the contractile function of the uterus or, conversely, to suppress it.

Medications also include anticonvulsants, preparations for women in labor with high blood pressure, cardiac, cerebral, nephrologic disorders. And in the presence of chronic inflammatory diseases can not do without antimicrobial and antibacterial drugs.

Central and peripheral cholinolytics (antispasmodics)

Excitation of muscarinic cholinergic receptors of the myometrium causes increased hydrolysis of phosphoinositides, activation of phospholipase A2, activation of protein kinase C, and contraction.

Dopaminergic drugs

Levodopa. Dioxyphenylalanine (DOPA or DOPA) is a biogenic substance formed in the body from tyrosine and is a precursor of dopamine, which in turn is converted into norepinephrine and then into adrenaline.

Beta-adrenoblockers and childbirth

Anaprilin (propranolol, obzidan, inderal). Anaprilin is a specific beta-blocker. The drug is well absorbed in the gastrointestinal tract, and therefore it is quite suitable for oral administration. The optimal dose (the concentration of anaprilin in the blood after oral administration of the drug is determined in the range from 45 to 120 minutes.

Anti-adrenergic drugs

Clonidine (gemiton, catapresan, clonidine) - has a pronounced hypotensive effect. Clonidine is used in therapeutic practice to treat hypertension. It has been established that with late toxicosis of pregnancy, the level of catecholamines in the blood increases, and the use of clonidine leads to hypotensive, sedative and slight diuretic effects.

N-Cholinolytics

Gangleron. The drug has ganglionic blocking, central cholinolytic, spasmolytic and anesthetic effects. Gangleron is a stable substance that slowly hydrolyzes in the body. It dilates blood vessels, causing a hypotensive effect.

Spasmoanalgesic Baralgin

Theoretically, any substance that, in a proportionate dose, weakens the spasm of smooth muscles caused by acetylcholine can be used as an antispasmodic. In practice, however, not all anticholinergic substances are used as antispasmodics.

Analgesics

Promedol (trimeperidine hydrochloride). Promedol is known to be a synthetic substitute for morphine and has a pronounced analgesic effect. A decrease in pain sensitivity under the influence of promedol develops after subcutaneous administration in 10-15 minutes.

Myorelaxants of central and peripheral action

In recent years, centrally acting muscle relaxants have been widely used in clinical practice. Due to the fact that, unlike peripherally acting muscle relaxants, they do not turn off spontaneous breathing, and do not have an adverse effect on the cardiovascular system and other vital organs and systems.

Tranquilizers in childbirth

From the group of minor tranquilizers, trioxazine, nozepam, phenazepam, sibazon (seduxen, diaepam) and others are used. Trioxazine. It has a moderate tranquilizing effect, combined with activation, some improvement in mood without drowsiness and intellectual inhibition, does not have a muscle relaxant effect.

Prostaglandins

Since 1970, natural prostaglandins have been used as therapeutic agents in obstetrics and gynecology for cervical ripening and early termination of pregnancy, for the purpose of labor induction and stimulation.