In general, a compound is considered "biologically active" if it is capable of interfering with the vital activity of skin cells or being incorporated into the biochemical processes taking place in the extracellular matrix.
Preservatives should provide protection of the cream from a wide range of organisms (bacteria, fungi) for a long time. Cosmetic products are used for several months (and even years), so the maintenance of preservatives is the storage conditions ...
Fragrances and preservatives - substances whose content in cosmetics is negligible - cause great concern to consumers. Therefore, in order to convince buyers of the safety of their products, some companies put a note on the cosmetics - "without perfumes" and / or "without preservatives".
The proportion of biologically active components in cosmetics is several percent (and sometimes even a fraction of a percent). Therefore, opening the jar with cosmetic means, we see above all the basis, and it lies on our skin.