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Scientists have proven that there should be different hours of administration for each medication
Last reviewed: 30.06.2025
In one of the educational institutions of Pennsylvania, specialists made an interesting discovery, as it turned out, during the day in the human body there are two main moments that affect the condition of tissues. In their work, scientists analyzed the work of DNA and cells of 12 animal tissues and identified significant changes that occurred early in the morning and in the evening.
Scientists believe that the changes taking place may affect the effectiveness of drugs, so when prescribing medications, doctors need to take this into account.
Circadian rhythms, or the biological (internal) clock of a person, influence many factors, including attention, mood, endurance, and even the likelihood of a heart attack. Cyclical fluctuations in the body affect biological processes that are associated with the change of day and night.
During the experiment, specialists periodically (every 120 minutes) analyzed samples of the cerebellum, skeletal muscles, lung muscles, hypothalamus, heart, brown and white fat, brainstem, aorta, adrenal glands, lungs, and kidneys.
As a result, they were able to establish that during the day, the activity of almost half of the genes associated with protein production changes. At the same time, special activity patterns were noted in different tissues and in different genes. The most dynamic changes occurred in the liver, in which more than three thousand genes work (642 genes work in the hypothalamus), and most drugs are metabolized in the liver.
This study once again confirmed the importance of observing the timing of taking medications, for example, statins, which help reduce cholesterol levels, are best taken in the evening, since cholesterol blockade most often occurs at night.
Circadian rhythms alternate the body's periods of sleep and wakefulness, so a person's internal clock can get out of order when changing time zones, especially when the transition is sudden. Mathematicians from the University of Michigan have developed a special mobile application that will help the body adapt to a new time zone in a short time.
After extensive research, experts have introduced an application called Entrain, which develops a schedule for the first days after arrival. For example, according to the schedule, you need to go for a walk at five o'clock in the morning and go to bed at seven o'clock in the evening, but despite the fact that the application's recommendations are a little strange at first glance, by following them you can adapt to the new conditions quite quickly.
For example, when flying from New York to London, where the time difference is five hours, the application offers a schedule according to which the body will return to normal in three days. According to the schedule compiled by Entrain, on the first day the morning should begin at 7-40, and at 9 pm "night" should come, i.e. the program recommends going to bed at this time. The next day, the program recommends waking up at 6-20 am, and at 7-40 pm "dark time of day" should come, i.e., if necessary, it is necessary to artificially darken the room. On the third day, according to the schedule, wake up at five in the morning, and "night" should come at 7-20 pm. At the same time, it is not necessary to go to bed at the specified time, you just need to try to clearly alternate the day and night regime.
If you need to go outside in the evening, the program recommends wearing glasses with pink lenses that block blue light. In some cases, the program, on the contrary, recommends turning on bright light at night, thereby "simulating" daytime.
As scientists say, following the program's recommendations is quite difficult, but they actually work. The program's calculations are partly based on calculations when a person's body temperature is lowered, usually a couple of hours before waking up.
Experts also recommend not eating during the flight, and then following the meal schedule drawn up by the program, which will speed up the process of the body's readjustment to the new time.
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