Tempalgin in pregnancy

Pregnancy is a natural process for the female body, accompanied by the restructuring of all metabolic reactions under the influence of hormones. Changes in hormonal levels lead to the emergence of mental instability. The woman becomes irritable, tearful, nervous, more sensitive to the influence of stressful situations. Such mental instability is often the cause of intense migraine-like headaches. A pregnant woman may also be bothered by other pains of various localizations and genesis (intestinal spasms, toothache, stomach pain, etc.).

If the pains appear regularly and systematically, this is a reason to contact a women's health clinic. To alleviate her condition with intense pain, a pregnant woman often resorts to those medications that she successfully used in similar situations before the gestation period. This is unacceptable.

All medications, the possibility of their use and risks for fetal development, as well as dosages should be discussed with the doctor monitoring the course of pregnancy. Self-medication during pregnancy is unacceptable and reckless. A pregnant woman should not focus only on her problems and ways to solve them, but also constantly remember the negative consequences for the future child from uncontrolled use of medications. Those medications that were successfully used and were effective before pregnancy can have an extremely negative effect on the fetus and lead to tragic consequences.

Tempalgin is a combination drug with a pronounced analgesic, good antipyretic, moderate anti-inflammatory and sedative effect. The combination of active ingredients (analgin and tempidol) can relieve pain of any origin within 20 minutes to 1 hour from the moment of taking the tablet. The analgesic effect lasts about 3-5 hours. Thanks to the anxiolytic tempidol, the effect of metamizole sodium (analgin) increases and a sedative effect on the body appears. The feeling of fear is dulled, increased nervousness and irritability are weakened, the anxiety state is reduced. In terms of time, sedation can last for quite a long time (6-7 hours).

Indications tempalgin during pregnancy

The medication is prescribed in the following cases:

• severe or moderate pain (hemicrania, cephalgia, algomenorrhea, odontalgia, etc.), accompanied by increased neuropsychic excitability,
• pain of visceral genesis and spastic nature (renal, intestinal, hepatic colic) of moderate or weak intensity. Tempalgin is used in combination with antispasmodic drugs,
• pain accompanying the postoperative period,
• pain arising after traumatic diagnostic examinations,
• odontalgia,
• neuralgia, arthralgia,
• in case of hyperthermia of the body during an infectious and inflammatory process, including colds.

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Release form

Tempalgin is produced exclusively in tablet form. The tablets are round, biconvex, covered with a green wafer, which dissolves well in the stomach and intestines. A blister contains 10 tablets. The original factory cardboard packaging contains 2 blisters of tablets (No. 20) or 10 blisters (No. 100).

Compound

One tablet of Tempalgin consists of:

• active ingredients:
• metamizole sodium – 500 mg,
• triacetonamine-4-toluenesulfonate – 20 mg,

Excipients:

• wheat starch, magnesium stearate, talc, microcrystalline cellulose.

Names of medications that have the same composition of active ingredients as tempalgin: "tempanginol", "tempimed", "tempanal".

Pharmacodynamics

Due to the combination of analgin and tempidol, the drug "tempalgin" has a prolonged analgesic and antipyretic effect. Metamizole sodium is capable of inhibiting prostaglandin synthesis, inhibiting cyclooxygenase of the first and second types, preventing the destruction of cell membranes, slowing down the increase in temperature. Tempidol reduces the feeling of anxiety, mental agitation and fear. Reduces motor excitability, prolongs and enhances the analgesic effect of Metamizol natrium. The onset of the analgesic effect is observed 20 minutes - 1 hour after taking tempalgin, the duration of the effect is 3-5 hours.

Pharmacokinetics

Active and complete absorption of Metamizolum natrium occurs in the gastrointestinal tract, where the substance binds to plasma proteins (80%). The maximum concentration of the substance in the blood is observed 30 minutes - 120 minutes (2 hours) after taking a tempalgin tablet. It is actively metabolized by the liver by oxidation. Metabolic products are excreted from the body by the intestines after 10 hours. In case of impaired renal filtering function, clearance may be prolonged.

Tempidon is absorbed in the upper intestine. It is metabolized by the liver and most of it is excreted from the body mainly in the urine as metabolites and slightly unchanged.

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Dosing and administration

The tablets are taken orally after meals, without chewing and with a sufficient amount of water.

Adults and children over 14 years of age are prescribed tempalgin 1 tablet x 3 times a day. If necessary, a single dose can be 2 tablets. The daily maximum dosage is 6 tablets.

The standard course of therapy is 5-7 days. With prolonged use of tempalgin, it is necessary to monitor peripheral blood indices. The dosage and duration of therapy with the drug is prescribed by a doctor.

Tempalgin can affect the speed of mental and motor reactions. Therefore, it is necessary to refrain from driving vehicles.

Use tempalgin during pregnancy during pregnancy

It is better to refuse to use tempalgin during gestation, especially in the first trimester and 1.5 months (6 weeks) before delivery, since it overcomes the placental barrier. It can be used in the second trimester in case of extreme necessity, when the benefit of therapy with this drug for the mother outweighs the risk of complications for the unborn child. The decision to prescribe tempalgin is made by the attending physician. It is more advisable to refuse to take this drug during gestation, minimizing the risks to the fetus. There are many other medications with a similar effect on the body and less dangerous for the unborn child.

To relieve pain of various origins, you can use folk methods. Only these means should be acceptable during the period of bearing a child.

Tempalgin during early pregnancy

The tablets contain analgin, known for its aggressive effect on erythropoiesis and granulocyte production. During prolonged use, it can cause agnulocytosis and suppression of the immune system's protective function, which leads to the risk of developing infectious diseases.

The use of analgin in the early stages of gestation may negatively affect the further development of the fetus and the progression of pregnancy. In the first trimester, all organs and systems of the unborn child are actively formed, and the negative impact of analgin may lead to disruption of the correctness of morphogenesis processes or provoke a miscarriage. Tempidon has sedative properties and prolongs the analgesic and antipyretic effects of analgin. There is no data on the effect of tempidon on the fetus. Based on the above, it is strictly forbidden to use tempalgin in the first trimester of gestation.

Tempalgin during pregnancy in the 2nd trimester

In the second trimester of pregnancy, the use of tempalgin tablets is less dangerous. But their prescription should be dictated by extreme necessity. The decision to take tempalgin or replace it with another medication or folk remedy should be made by the attending obstetrician-gynecologist. A reasonable permissible maximum is a single dose of tempalgin tablet.

Tempalgin during pregnancy in the 3rd trimester

During this period, the woman's body is actively preparing for childbirth. The production of prostaglandins increases, reaching a maximum level during contractions. These substances, having reached a certain concentration, cause the onset of labor. Therefore, taking drugs containing analgin in the last weeks before childbirth is undesirable. By causing suppression of prostaglandin production, taking analgin can lead to a violation of the intensity of labor, cessation of contractions, or provoke a post-term pregnancy, which is dangerous for the mother and the unborn child.

Self-medication and uncontrolled use of medications during gestation is dangerous, therefore the use or discontinuation of all medications is determined by the doctor.

Contraindications

• hypersensitivity to the components of the drug;
• suppression of hematopoiesis (may be expressed by leukopenia, agranulocytosis, granulocytopenia, aplastic anemia);
• disorders of the excretory system;
• heart failure;
• gestation (first trimester and 1.5 months before birth);
• breastfeeding period;
• children under 14 years old.

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Side effects tempalgin during pregnancy

The drug tempalgin can cause side effects.

• Gastrointestinal tract - nausea, epigastric pain, xerostomia, cholestasis, increased transaminase levels.
• Cardiovascular system - increased heart rate, hypotension or hypertension.
• Respiratory system: the possibility of bronchospasm and attacks of bronchial asthma cannot be excluded.
• CNS - "illusions of movement", cephalgia.
• Urogenital system: pathologies of the renal filtration function (if the dosage and duration of the course of treatment are exceeded). Urine may be colored red.
• Hematopoiesis - thrombocytopenia, leukopenia, granulocytopenia.
• Allergic manifestations include pruritus, burning, exanthema, urticaria, Quincke's edema and anaphylactic shock.

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Overdose

Symptoms of a tempalgin overdose include shortness of breath, increased heart rate, pain in the epigastric region, nausea, vomiting, decreased blood pressure, drowsiness, confusion, and seizures.

Treatment of overdose with tempalgin should be carried out in a medical institution. In the clinic, gastric lavage is performed. Various sorbents are used and symptomatic therapy is carried out aimed at supporting vital organs and systems (hemodialysis, forced diuresis, anticonvulsant therapy).

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Interactions with other drugs

Tempalgin stimulates the action of ethanol.

When using tempalgin together with timazole and cytostatics, the risk of developing leukopenia increases.

Tranquilizers and sedatives enhance the analgesic effect of the drug.

Codeine and propanol prolong the elimination of analgin from the body.

When tempalgin is taken together with barbiturates, the effect of analgin is weakened.

Tempalgin tablets, when taken simultaneously with chlorpromazine, can provoke severe hyperthermia.

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Storage conditions

The tablets should be stored under the following conditions: a dry place, impermeable to direct sunlight, with a temperature of 25 degrees.

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Shelf life

The medicine is valid for 48 months from the date of manufacture. Do not use tempalgin after the expiration date. The date of manufacture and expiration date are indicated on the blister and the original factory cardboard packaging.

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