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The reaction of inhibition of migration of leukocytes in the blood

 
, medical expert
Last reviewed: 18.10.2021
 
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The values of the inhibition of migration of leukocytes in the blood are normal: migration with phytohemagglutinin (PHA) is 20-80%, with concanavalin A (ConA) 40-75%, with a specific antigen 80-120%.

The reaction of inhibition of migration of leukocytes allows one to assess the ability of T-lymphocytes to produce lymphokines in response to antigenic stimulation. This test evaluating the functional activity of T-lymphocytes can be used to diagnose immunological failure (reaction with mitogens), hypersensitivity (allergies) of delayed type (reaction with a specific antigen or allergen). The inhibition of migration of leukocytes can also be used to detect an immune response to infectious agents, to determine the degree of histocompatibility and in tumor processes.

This test characterizes the activity of the inflammatory process. An increase in the inhibition of migration of leukocytes should be considered as a prognostically favorable factor; clinically it is accompanied by faster recovery of patients with acute surgical diseases after surgical intervention and shortening of the postoperative period. The inhibition of migration of leukocytes can be very significant in allergic reactions. Diseases and conditions leading to a change in the inhibition of migration of leukocytes

Increase in the

  • Functional deficiency of T-lymphocytes, immunodeficiency (including HIV infection), congenital defects of the T-link of immunity
  • Chronic inflammation
  • Neoplasms
  • Heavy burns, injuries, stress
  • Intestinal and renal protein loss syndromes, aging
  • Malnutrition
  • Treatment with cytostatics and immunosuppressants
  • Ionizing radiation

Decrease in the indicator

  • Reduction of migration with a specific antigen or allergen testifies to the sensitization of lymphocytes to these antigens (allergies)
  • Reduction of migration with mitogens testifies to the hyperactivity of the immune system in allergic and autoimmune diseases
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