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Age-related changes in cellular immunity in children
Last reviewed: 23.04.2024
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In the diagnosis of various disease states in the immunocompetent system of both the fetus and the newborn child and children of later life periods, methods of determining the degree of maturity and differentiation of individual populations or subpopulations of lymphocytes are of great importance. Determine the relative and absolute contents of lymphocytes with those or other immunological marker signs. There are normative data for judging the degree of norm or pathological deviations in the population composition of blood lymphocytes in children of different ages and adults.
The number of lymphocytes and their subpopulations in human umbilical cord blood
|
Indicators |
Relative,% |
Absolute, μL | ||
|
Minimum |
Maximum |
Minimum |
Maximum | |
|
Leukocytes |
- |
- |
10 LLC |
15,000 |
|
Lymphocytes |
35 |
47 |
4200 |
6900 |
|
CD3 (T-cells) |
49 |
62 |
2400 |
3700 |
|
CD4 (T-helpers) |
28 |
42 |
1500 |
2400 |
|
CD8 (T-killers) |
26th |
33 |
1200 |
2000 |
|
CD4 / CD8 |
0.8 |
1.8 |
- |
- |
|
CD16 (NK cells) |
8 |
17th |
440 |
900 |
|
CD20 (B-lymphocytes) |
14 |
23 |
700 |
1500 |
|
CD25 (receptor for IL-2) |
5.5 |
10 |
302 |
550 |
|
HLA II |
16 |
27th |
880 |
1485 |
The number of lymphocytes and their subpopulations in peripheral blood of children under 1 year
|
Indicators |
Relative,% |
Absolute, μL | ||
|
Minimum |
Maximum |
Minimum |
Maximum | |
|
Leukocytes |
- |
- |
6400 |
11 000 |
|
Lymphocytes |
39 |
59 |
2700 |
5400 |
|
CD3 (T-cells) |
58 |
67 |
1900 |
3600 |
|
CD4 (T-helpers) |
38 |
50 |
1500 |
2800 |
|
CD8 (T-killers) |
18 |
25 |
800 |
1200 |
|
CD4 / CD8 |
1.5 |
2.9 |
- |
- |
|
CD16 (NK cells) |
8 |
17th |
300 |
700 |
|
CD20 (B-lymphocytes) |
19 |
31 |
500 |
1500 |
|
CD25 (receptor for IL-2) |
7th |
12 |
280 |
360 |
|
HLA II |
25 |
38 |
1000 |
1520 |
The number of lymphocytes and their subpopulations in peripheral blood of children 1-6 years
|
Indicators |
Relative,% |
Absolute, μL | ||
|
Minimum |
Maximum |
Minimum |
Maximum | |
|
Leukocytes |
- |
- |
4700 |
7300 |
|
Lymphocytes |
36 |
43 |
2000 |
2700 |
|
CD3 (T-cells) |
66 |
76 |
1400 |
2000 |
|
CD4 (T-helpers) |
33 |
41 |
700 |
1100 |
|
CD8 (T-killers) |
27th |
35 |
600 |
900 |
|
CD4 / CD8 |
1.0 |
1.4 |
- |
- |
|
CD16 (NK cells) |
9 |
16 |
200 |
300 |
|
CD20 (B-lymphocytes) |
12 |
22 |
300 |
500 |
|
CD25 (receptor for IL-2) |
10 |
16 |
230 |
368 |
|
HLAII |
19.5 |
39 |
449 |
897 |
The number of lymphocytes and their subpopulations in human peripheral blood of 18-60 years
|
Indicators |
Relative,% |
Absolute, μL | ||
|
Minimum |
Maximum |
Minimum |
Maximum | |
|
Leukocytes |
- |
- |
4000 |
8000 |
|
Lymphocytes |
28 |
39 |
1600 |
2400 |
|
CD3 (T-cells) |
50 |
76 |
800 |
1216 |
|
CD4 (T-helpers) |
31 |
46 |
500 |
900 |
|
CD8 (T-killers) |
26th |
40 |
416 |
640 |
|
CD4 / CD8 |
1.0 |
1.5 |
- |
- |
|
CD16 (NK cells) |
9 |
16 |
170 |
400 |
|
CD20 (B-lymphocytes) |
Eleven |
16 |
200 |
400 |
|
CD25 (receptor for IL-2) |
13 |
24 |
208 |
576 |
|
HLA II |
19 |
Thirty |
340 |
720 |
|
CD95 |
5 |
7th |
90 |
112 |
Characteristics of the characteristics of the immune response are largely determined by the ability of participating cells to produce substances of humoral communication and regulation - cytokines or interleukins. In scientific research, several dozens of such information and regulatory molecules have been identified and quantified. In clinical immunology, the most important is the determination of 10-15 biologically active substances of this group.
Naturally, in the diagnosis of paramount importance are research methods that carry the ability to quantify the production of certain active molecules. This is particularly convincingly achieved in stimulation or induced synthesis reactions under standard culture conditions of lymphocytes.
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