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Indications for immune status testing
Medical expert of the article
Last reviewed: 06.07.2025
The following diseases and conditions are considered indications for the appointment of an analysis of the immune status (immunological studies).
- Suspected presence of genetically determined defects of the immune system (primary immunodeficiencies).
- Autoimmune diseases.
- Allergic conditions and diseases.
- Infectious diseases with a protracted and chronic course.
- Suspected acquired immunodeficiency.
- Malignant neoplasms.
- Conducting cytostatic, immunosuppressive and immunomodulatory therapy.
- Preparation for major surgical interventions and complicated postoperative period.
- Examination of recipients before and after organ allotransplantation.
The study of immune status currently includes an assessment of the following components:
- antigen-specific (humoral and cellular immunity);
- antigen-nonspecific (the body's nonspecific resistance system).
In this case, antigen-specific factors include humoral and cellular immune responses. The first is based on the production of antibodies, the second - on the action of activated thymus-dependent lymphocytes (T-lymphocytes). The humoral immune response is characterized by the production of antibodies, which are simultaneously effectors of the B-link of the immune system. To assess this link, studies are used that characterize the functional activity of the B-link of immunity and include determining Ig concentrations, antibody levels after prophylactic immunization, and identifying the CIC. The cellular type of response is characterized by the production of a large number of antigen-specific activated B- and T-lymphocytes. An optimal immune response is realized only with the interaction of the humoral and cellular links of immunity.
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