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T-lymphocytes with interleukin-2 (CD25) receptors in the blood
Medical expert of the article
Last reviewed: 18.10.2021
Normally, the number of CD25-lymphocytes in the blood in adults is 13-24%.
CD25 - activated T-lymphocytes, stimulating antibody formation and cytotoxicity. This indicator reflects the ability of lymphocytes to proliferate and differentiate and characterizes the functional state of activated T-lymphocytes. A reduced number indicates immunological deficiency of the cellular immunity. With the hyperactivity of immunity, the number of these cells increases.
Diseases and conditions leading to changes in the number of CD25-lymphocytes in the blood
Increase in the
- Hyperactivity of the immune system in allergic and autoimmune diseases
- Activation of anti-transplantation immunity, a crisis of rejection of donor organs in recipients
- Immune response to thymus-dependent antigens
- In acute period of primary infection
Decrease in the indicator
- Oncological diseases
- Secondary immunodeficiency states, HIV infection
- Congenital defects of the immune system
- Severe viral infections
- Heavy burns, injuries, stress
- Treatment with cytostatics and immunosuppressants
- Ionizing radiation
- Admission of glucocorticosteroids