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Spontaneous lymphocyte blast transformation reaction
Medical expert of the article
Last reviewed: 05.07.2025
The magnitude of spontaneous blast transformation of lymphocytes in adults is normally up to 10%.
Spontaneous blast transformation of lymphocytes is the ability of lymphocytes to transform without stimulation. The study is performed to assess the functional activity of T-lymphocytes.
Diseases and conditions in which spontaneous blast transformation of lymphocytes is altered
Increase in the indicator
- Hyperactivity of the immune system in allergic and autoimmune diseases
- Activation of anti-transplant immunity
- Donor Organ Rejection Crisis
- Acute period of primary infection
- Immune response to thymus-dependent antigens
Decrease in the indicator
- Oncological diseases
- Secondary immunodeficiency states
- Congenital defects of the immune system, HIV infection
- Severe viral infections
- Severe burns, injuries
- Treatment with cytostatics and immunosuppressants
- Ionizing radiation
- Taking glucocorticosteroids
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