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Serum creatinine

Medical expert of the article

Hematologist, oncohematologist
, medical expert
Last reviewed: 05.07.2025

Creatinine is the end product of creatine breakdown, which plays an important role in the energy metabolism of muscle and other tissues. Creatine is synthesized mainly in the liver, from where it enters muscle tissue with the bloodstream. Here, creatine, phosphorylated, turns into creatine phosphate. Creatine phosphate is a macroergic compound and participates in the transfer of energy in the cell between mitochondria and myofibrils. The concentration of creatinine in the blood depends on its formation and excretion. Creatinine formation directly depends on the state of muscle mass. Creatinine is excreted by the kidneys through glomerular filtration, but, unlike urea, is not reabsorbed, which has found application in laboratory diagnostics (Reberg-Tareev test).

The concentration of creatinine in the blood of healthy people is a fairly constant value and depends little on nutrition and other extrarenal factors.

Determination of serum creatinine concentration is widely used in diagnostics of kidney diseases. Creatinine is less dependent on the level of catabolism, is not reabsorbed in the kidneys, and therefore reflects the degree of impairment of the excretory and filtration functions of the kidneys to a greater extent. A decrease in creatinine content in the blood has no diagnostic value.

Reference values (norm) of creatinine concentration in blood serum

Serum creatinine concentration

Age

µmol/l

Mg/dl

Newborns

27-88

0.3-1.0

Children under 1 year

18-35

0.2-0.4

Children from 1 year to 12 years

27-62

0.3-0.7

Teenagers

44-88

0.5-1.0

Adults:

Men

62-132

0.7-1.4

Women

44-97

0.5-1.1

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