NK-lymphocytes (CD16) in the blood

, medical expert
Last reviewed: 19.11.2021

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Normally, the number of CD16-lymphocytes in the blood in adults is 6-26%.

CD16-lymphocytes are effector cells responsible for antitumor, antiviral and transplantation immunity. NK cells are a separate population of lymphocytes, they differ from T and B lymphocytes both in origin and in functional properties and surface receptors (in humans there are 2 subpopulations - CD16 and CD56). They have spontaneous cytotoxic activity against various tumor cells, cells infected with viruses and some normal cells, providing the first level of protection against tumors and intracellular infections before the incorporation of specific immune mechanisms. Unlike other cytotoxic cells, NK cells mediate cytotoxic reactions without presensitization and without restrictions on the expression of class I or II antigens of the main histocompatibility complex on target cells. High cytotoxicity and the ability to produce many cytokines are the main properties of CD16 lymphocytes. Reducing the number of CD16-lymphocytes leads to the development of cancer and weighting of the course of viral infections, autoimmune diseases, an increase - to the crisis of rejection of transplanted organs in recipients.

trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]

Translation Disclaimer: The original language of this article is Russian. For the convenience of users of the iLive portal who do not speak Russian, this article has been translated into the current language, but has not yet been verified by a native speaker who has the necessary qualifications for this. In this regard, we warn you that the translation of this article may be incorrect, may contain lexical, syntactic and grammatical errors.

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.