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Neurotensinoma: causes, symptoms, diagnosis, treatment
Last reviewed: 23.04.2024
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Neurotensinoma - individual neurotensin-producing cells (N-cells) are found in the pancreatic gastrinoma. On the predominantly neurotensin-producing tumors, there are still few reports. The first description of a similar tumor was made by V. Holmstaedter et al. In 1979. Neurotensinos along with neurotensin also contain gastrin, PP and glucagon in a ratio of 79: 18: 3: 1. The concentration of these hormones in serum is also increased accordingly. In the described cases, the tumor was a benign adenoma of the head of the pancreas, consisting mainly of N-cells, immunocytochemically reacting with neurotensin antibodies.
Symptoms of neurotensinoma are due to the presence of accompanying hypergastrinemia - Zollinger-Ellison syndrome. Until now, it remains unclear which clinical signs of neurotensinoma are inherent in hyperneurotension. It was reported that in each case, after a total gastrectomy, there was massive sheep esophageal reflux, which may be related to the effect of neurotensin on the motility of the duodenum. Further observations are needed to determine clinical correlations with hyperneurotension.
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