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Morgagnes-Stewart-Morel syndrome: causes, symptoms, diagnosis, treatment
Medical expert of the article
Last reviewed: 07.07.2025
Morgagni-Steward-Morel syndrome is characterized by thickening of the inner plate of the frontal part (frontal hyperostosis), general obesity with a pronounced double chin and fatty apron, usually without stretch marks on the skin, often intracranial hypertension, menstrual irregularities, hirsutism, severe headaches mainly in the frontal and occipital localization, memory loss, depression, diabetes mellitus. It is possible, although quite rare, to develop symptoms of diabetes insipidus. The syndrome is more typical for women and most often debuts during the climacteric period. However, it can also occur at a younger age (up to 30 years). Incomplete forms of the syndrome are most common. It is extremely rare in men.
Causes of Morgagni-Stuard-Morel syndrome
Refers to hereditary diseases. Inherited in an autosomal dominant manner.
Pathogenesis of Morgagni-Steward-Morel syndrome
Dysfunction of the hypothalamic-pituitary region with excessive production of STH and ACTH as a result of hyperfunction of eosinophilic and basophilic cells of the adenohypophysis. Hyperfunction is induced by hypothalamic releasing factors.
Treatment of Morgagni-Steward-Morel syndrome
It should be aimed at relieving the main manifestations of the disease - obesity, arterial hypertension, depression.
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