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Lymphoma of conjunctiva: causes, symptoms, diagnosis, treatment

Medical expert of the article

Hematologist, oncohematologist
, medical expert
Last reviewed: 07.07.2025

The conjunctiva may be a site of lymphoid tissue proliferation, presenting these lesions as both benign and atypical hyperplasia and lymphoma. Benign and malignant lesions have similar features and are therefore clinically difficult to differentiate. Sometimes reactive hyperplasia undergoes malignant transformation into lymphoma. Most conjunctival lymphomas consist of B-lymphocytes and are accompanied by systemic changes in 30% of cases.

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Symptoms of Conjunctival Lymphoma

Conjunctival lymphoma usually presents in old age with eye irritation or painless swelling. Slowly growing, mobile, pinkish-yellow or flesh-colored infiltrates located in the inferior fornix or epibulbarly. May be bilateral. Lesions may be limited to the conjunctiva or extend into the orbit.

Rarely, diffuse conjunctival lymphoma may mimic chronic conjunctivitis.

What do need to examine?

How to examine?

Treatment of conjunctival lymphoma

Radiation therapy is the most commonly used. Other treatments include chemotherapy, surgical excision, cryotherapy, and local injections of interferon alpha-2b.

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