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Leflocin

Medical expert of the article

Internist, pulmonologist
, medical expert
Last reviewed: 04.07.2025

Leflocin is an effective antimicrobial drug from the fluoroquinolone subgroup. Its active ingredient is levofloxacin, which demonstrates a wide range of bactericidal effects.

According to the principle of its therapeutic activity, levofloxacin acts by slowing down the activity of DNA gyrase, which ultimately leads to disruption of the processes of microbial DNA replication. [ 1 ]

The medication is used to eliminate infections associated with the activity of bacteria that demonstrate sensitivity to levofloxacin.

ATC classification

J01MA12 Levofloxacin

Active ingredients

Левофлоксацин

Pharmacological group

Антибактериальные средства для системного применения
Хинолоны / фторхинолоны

Pharmachologic effect

Антибактериальные широкого спектра действия препараты

Indications Leflocin

It is used for infectious lesions of different localizations associated with the activity of microbes that die under the influence of levofloxacin. Among these:

  • infections of the respiratory tract and ENT system;
  • lesions of the subcutaneous layer and epidermis, and in addition, the organs of the peritoneum;
  • diseases affecting the urinary tract;
  • gynecological infections.
  • Along with this, the medication is prescribed for gonorrhea, osteomyelitis, as well as septicemia, dysentery, meningitis and salmonellosis.

The drug is also used to prevent infections during surgery.

Release form

The drug is released in the form of an infusion liquid - inside vials with a capacity of 0.05, 0.1 or 0.2 l, and in addition inside polymer containers with a capacity of 0.1 or 0.2 l.

Pharmacodynamics

The drug is effective against strains of gram-negative and -positive aerobes with intracellular microbes. Among them are enterobacter, pseudomonads with salmonella, serratia and shigella with yersinia, citrobacter with proteus, neisseria and intestinal sticks. In addition, also providencia, staphylococci, chlamydia, hemophilic rods with streptococci, campylobacter, Plesiomonas spp., hafnia, brucellae with Vibrio spp. and Aeromonas spp.

Leflocin also affects bacteria that produce β-lactamases (including non-fermenting microbes). Among such microorganisms are strains of Mycoplasma pneumoniae, Legionella pneumophila, Ureaplasma, Chlamydia pneumoniae, as well as Chlamydia trahomatis, Mycobacteria and Helicobacter pylori. [ 2 ]

Treponema pallidum has resistance to drugs. [ 3 ]

Pharmacokinetics

The active element of the medicine forms high values inside the gall bladder, epidermis with bones, lung tissue and prostate. Its high values are also observed inside saliva with urine, sputum and bronchial secretions.

Approximately 30-40% of the drug is involved in protein synthesis.

The active substance of the drug is excreted largely unchanged through the kidneys. The half-life is in the range of 6-8 hours.

Dosing and administration

The medication is administered by intravenous infusion - through a dropper. The drug can be used at a rate of no more than 0.1 l/hour. Taking into account the severity of the disease, after several days from the start of treatment, the patient is transferred to the use of levofloxacin orally, while maintaining the daily dosage. The duration of treatment is selected by the attending physician; the drug should be continued for at least 2 days from the moment the clinical symptoms of the pathology disappear.

If the daily dose of the drug is no more than 0.5 g, it is used in 1 infusion. If the daily dose is more than 0.5 g, it can be divided into 2 infusions at the discretion of the attending physician.

Levofloxacin dosage sizes prescribed to individuals with healthy renal function.

In case of community-acquired pneumonia, 0.5-1 g of Lefloxacin is often administered per day.

Infections in the urinary tract that occur with complications require the use of 0.25 g of the drug per day. If the infection is severe, the attending physician may increase the daily dosage of the drug.

In case of damage to subcutaneous tissues and epidermis, and also in case of bacteremia or septicemia, 0.5-1 g of the drug should be administered per day. In persons with septicemia or bacteremia, treatment should continue for at least 10 days.

In case of abdominal infections, the drug is used in combination with other antimicrobial substances that demonstrate activity against anaerobes. In case of such diseases, 0.5 g of levofloxacin is administered per day.

Treatment usually lasts at least 7 days. However, its maximum permissible duration is 2 weeks.

Use of the drug in people with renal dysfunction.

Dosage portions should be adjusted taking into account the CC indicators.

For people with a CC level in the range of 20-50 ml per minute, it is necessary to initially use 0.25 g of the drug per day; from the 2nd day of treatment, the daily dose is reduced to 125 mg. In case of severe stages of infection, the first daily dose of the drug is increased to 0.5 g, and then the patient is transferred to the use of 0.25 g, with administration at 12-24 hour intervals.

For individuals with CC values within 10-19 ml per minute, a daily dose of 0.25 g is administered, and then, on the 2nd day of therapy, 125 mg of the drug is used (once every 2 days). Severe infections require the administration of the first dose of the drug in the amount of 0.5 g per day, and then a transition to the use of 125 mg of the drug with 12-24-hour breaks is made.

People with a CC level below 10 ml per minute (also those on hemodialysis) are often given 0.25 g of the drug, and from the 2nd day they begin to administer 125 mg at 48-hour intervals. Severe lesions require the administration of 0.5 g on the 1st day of treatment, and then the use of 125 mg with a single administration over 24 hours.

  • Application for children

The medication is not prescribed in pediatrics (before the age of 18), as it can provoke disorders in the development of cartilage tissue.

Use Leflocin during pregnancy

Leflocin should not be used during pregnancy. Before starting therapy with this medicine, the patient should be examined to rule out possible pregnancy. Since the medicine can lead to disorders in the development of joint tissues, it is not used in pregnant women, during breastfeeding, and in addition during the growth period.

If there is a need to use drugs during breastfeeding, breastfeeding should be stopped for the duration of treatment.

Contraindications

The drug is not used in case of personal hypersensitivity to levofloxacin and other antimicrobial substances from the quinolone subcategory.

It should not be used in people with diseases that cause prolongation of the QT interval, or in epileptics.

Contraindicated for use in individuals with G6PD deficiency and porphyria.

It is used with extreme caution in elderly people (especially in people who are also undergoing treatment with GCS), as well as in people with atherosclerotic lesions in the cerebral vessels, renal pathologies and cerebral circulatory disorders, as well as in chronic alcoholism.

Side effects Leflocin

The main side effects when using the medication:

  • disorders of the PNS and CNS: headaches, depression, dizziness, severe fatigue, nightmares, problems with daily routine, unexplained anxiety, hyperkinesia, auditory, taste and olfactory disorders and convulsions;
  • problems associated with the hematopoietic system and cardiovascular system: thrombocyto-, pancyto- or leukopenia, hemolytic anemia, tachycardia, agranulocytosis, decreased blood pressure and eosinophilia;
  • disorders of liver function and gastrointestinal tract function: pain in the epigastric region, vomiting, melena, bowel disorders, anorexia and nausea, as well as hepatitis, hyperbilirubinemia and increased activity of intrahepatic enzymes. Pseudomembranous colitis occurs occasionally;
  • signs of allergy: photophobia, epidermal itching, Quincke's edema and urticaria;
  • Others: acute renal failure or nephrotic syndrome, pain in the joints and muscles, superinfection, decreased visual acuity and hypoglycemia. Hyperemia and pain in the injection area may also develop.

Overdose

The use of large doses of the drug can provoke seizures, dizziness, development of confusion and mental disorders in patients. Subsequent increase in dosage leads to prolongation of the QT interval.

There is no antidote. In case of poisoning, symptomatic actions are taken, as well as procedures that support cardiac activity. In case of intoxication, the patient should be under medical supervision; among other measures, ECG indicators are monitored.

Peritoneal and hemodialysis will be ineffective in case of levofloxacin overdose.

Interactions with other drugs

The drug should be used with extreme caution when administered to people using substances that reduce seizure readiness (including theophylline and NSAIDs).

Probenecid with cimetidine when used in combination with levofloxacin leads to a slowdown in its excretion.

When combining Lefloxacin with ethanol, the inhibitory effect of levofloxacin on the central nervous system is potentiated.

The drug can be used together with Ringer's solution, 0.9% infusion NaCl, 5% infusion glucose and amino acid solutions.

The drug cannot be combined with infusion fluids that have an alkaline effect and with heparin.

Storage conditions

Leflocin should be stored in a dark place. The liquid should not be frozen. Temperature indicators should not exceed 25 °C.

Shelf life

Leflocin can be used within 24 months from the date of production of the therapeutic substance. When stored under the influence of sunlight, the shelf life of the drug is 3 days.

Analogues

The analogs of the drug are Loxof, Levoflox with Abiflox, Levofloxacin, Tavanic and Flexid with Tigeron, and in addition to this, Glevo, Floracid with L-Flox and Levomak. Also on the list are Oftaquix, Levobax with Leflobact, Eleflox and Levoximed.


Attention!

To simplify the perception of information, this instruction for use of the drug "Leflocin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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