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Causes of increases and decreases in suppressor T-lymphocytes (CD8)
Medical expert of the article
Alexey Kryvenko, medical expert
Last reviewed: 04.07.2025
Last reviewed: 04.07.2025
Diseases and conditions that lead to changes in the number of CD8 lymphocytes in the blood
Increase in the indicator
- Autoimmune diseases
- Systemic lupus erythematosus
- Sjögren's syndrome, Felty
- Rheumatoid arthritis
- Systemic sclerosis, collagenoses
- Dermatomyositis, polymyositis
- Liver cirrhosis, hepatitis
- Waldenstrom's disease
- Acquired hemolytic anemia, thrombocytopenia
- Mixed connective tissue diseases
- Activation of anti-transplant immunity
- Primary immunodeficiency states
Decrease in the indicator
- Acquired secondary immunodeficiency states:
- bacterial, viral, protozoal infections with protracted and chronic course tuberculosis, leprosy, HIV infection malignant neoplasms
- Severe burns, injuries, stress
- Aging
- Treatment with cytostatics and immunosuppressants
- Ionizing radiation (in the acute period)
- Enhancement of suppressive activity of cellular immunity