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Causes of increased and decreased phagocytic activity of neutrophils
Medical expert of the article
Alexey Kryvenko, Medical Reviewer, Editor
Last reviewed: 06.07.2025
Last reviewed: 06.07.2025
Diseases and conditions in which the phagocytic activity of neutrophils is altered
Increase in the indicator
- Antigenic irritation due to bacterial inflammation (prodromal period, period of acute manifestation of infection) with normal phagocytosis activity
- Leukocytosis
- Allergy
- Autoallergic diseases
- Enhancement of antibody-dependent cytotoxicity and donor graft response
Decrease in the indicator
- Chronic inflammatory diseases of bacterial and viral origin
- Congenital defects of the phagocytic system, Shediak-Higashi syndrome, Down's syndrome, SLE, collagenoses, immune complex diseases, Ig deficiency, complement
- Treatment with cytostatics and immunosuppressants
- Ionizing radiation
- Secondary and primary immunodeficiencies
- New growths
- Severe burns, injuries, stress
- Intestinal and renal protein wasting syndromes
- Malnutrition
- Phagocytosis deficiency
- Chronization of the inflammatory process