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Causes of immunoglobulin G increase and decrease
Medical expert of the article
Last reviewed: 04.07.2025
A decrease in the content of immunoglobulin G indicates a deficiency of humoral immunity.
Changes in serum immunoglobulin G concentration in various diseases
| Increased concentration | Decreased concentration |
Acute and chronic bacterial, fungal and parasitic infections Acute and chronic liver diseases Liver cirrhosis, viral hepatitis Autoimmune diseases Rheumatoid arthritis Collagenoses, rheumatism Systemic lupus erythematosus Sarcoidosis, cystic fibrosis Waldenstrom's disease Myeloma disease Monoclonal gammopathy Infectious mononucleosis Chronic lymphocytic leukemia Convalescence after bacterial infection Acute period of re-infection |
Physiological hypogammaglobulinemia (in children aged 3-5 months), congenital hypogammaglobulinemia or agammaglobulinemia Hemoglobinopathies Diseases that lead to depletion of the immune system:
Treatment with cytostatics and immunosuppressants, ionizing radiation Chronic viral infection |