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Antibodies to single-stranded DNA in serum
Medical expert of the article
Last reviewed: 04.07.2025
Normally, the concentration of antibodies to single-stranded DNA (anti-ssDNA) in the blood serum is less than 300 IU/ml; 300-350 IU/ml are borderline values.
Antibodies to single-stranded DNA are found in rheumatic diseases as well as in other somatic and infectious diseases. However, their titer is most often increased in systemic lupus erythematosus and scleroderma, especially in active and malignant forms.
Frequency of detection of antibodies to single-stranded DNA in blood serum in systemic lupus erythematosus and other collagenoses
Diseases |
Detection rate,% |
Systemic lupus erythematosus: |
65 |
Active |
78 |
Inactive |
43 |
Rheumatoid arthritis |
35 |
Systemic scleroderma |
50 |
Localized scleroderma |
0 |
Healthy |
0 |
When evaluating the results of determining antibodies to single- and double-stranded DNA, it should be taken into account that many inflammatory or other processes accompanied by tissue destruction can lead to an increase in the titer of these antibodies in the blood serum.
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