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Antibodies to neutrophil myeloperoxidase in blood
Medical expert of the article
Last reviewed: 05.07.2025
Normally, antibodies to neutrophil myeloperoxidase are absent in the blood serum.
Myeloperoxidase is a protein with a molecular weight of 59,000, which is one of the main factors providing human bactericidal protection. Antibodies to neutrophil myeloperoxidase may appear in vasculitis (microscopic polyangiitis - in 60-65% of cases, Churg-Strauss - in 17-20%), rheumatoid arthritis, systemic lupus erythematosus, Goodpasture's syndrome.
Frequency of detection of different types of antibodies in vasculitis
AT detection rate,% |
|||
Type of AT |
Wegener's granulomatosis |
Microscopic polyangiitis |
Churg-Strauss syndrome |
| ANCA | 85-95 |
75-95 |
65-75 |
| AT to protein kinase-3 | 75-80 |
25-35 |
10-15 |
Anti-MP |
10-15 |
50-60 |
55-60 |
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