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Antibodies to neutrophil myeloperoxidase in blood

Medical expert of the article

Pediatric immunologist
, medical expert
Last reviewed: 05.07.2025

Normally, antibodies to neutrophil myeloperoxidase are absent in the blood serum.

Myeloperoxidase is a protein with a molecular weight of 59,000, which is one of the main factors providing human bactericidal protection. Antibodies to neutrophil myeloperoxidase may appear in vasculitis (microscopic polyangiitis - in 60-65% of cases, Churg-Strauss - in 17-20%), rheumatoid arthritis, systemic lupus erythematosus, Goodpasture's syndrome.

Frequency of detection of different types of antibodies in vasculitis

AT detection rate,%

Type of AT

Wegener's granulomatosis

Microscopic polyangiitis

Churg-Strauss syndrome

ANCA

85-95

75-95

65-75

AT to protein kinase-3

75-80

25-35

10-15

Anti-MP

10-15

50-60

55-60

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