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Zorex
Medical expert of the article
Last reviewed: 23.04.2024
Zorex has hepatoprotective, antioxidant, complexing and detoxifying properties.
ATC classification
Active ingredients
Pharmacological group
Pharmachologic effect
Indications Zorexa
It is used for such violations:
- alcohol abstinence (to prevent the development of a hangover or its treatment);
- chronic alcoholism (part of the combination therapy);
- having chronic or acute intoxication, developing under the influence of inorganic or organic compounds of some components (mercury, bismuth, chromium with zinc, arsenic, nickel, gold with copper, cadmium with antimony and cobalt);
- poisoning associated with the use of SG.
Release form
The release of the substance is realized in capsules with a volume of 150 + 7 mg (10 pieces inside the box) or 250 + 10 mg (2 or 5 pieces inside the plate, 1-2 plates inside the box).
Pharmacodynamics
Zorex is a complexing agent and donor of thiol categories. It has detoxification activity (also in relation to the metabolic products of ethyl alcohol, arsenic compounds, and at the same time heavy metals with their compounds). In clinical tests, it was found that unitol has a hepatoprotective and antioxidant effect.
The presence of active categories of sulfhydryl character promotes the interaction of unithiol with thiol nuclei, and at the same time with the metabolic products of ethyl alcohol located inside the tissues with blood, and the formation of ligaments with them (they do not have toxic properties and are excreted with urine).
With oral use of drugs, unitiol reaches the liver, where it forms physiologically irreversible compounds with acetaldehyde at high speed. Due to this, alcohol (ethanol) is excreted from other tissues with organs. The drug stimulates the activation of the enzyme alcohol dehydrogenase, which potentiates the oxidative processes associated with ethyl alcohol and helps the enzyme liver system to neutralize its toxic agents.
Pantothenate, which is contained within the drug, is able to potentiate the detoxification activity that unithiol has. This element is absorbed at high speed inside the intestine, after which it is broken down to release pantothenic acid. It participates in the metabolism of fats with carbohydrates, stimulates the formation of corticosteroids and significantly speeds up the recovery.
Pharmacokinetics
Absorption is carried out at high speed. After oral administration of the 1st capsule (0.25 g unitol), the blood values of Cmax are determined after 1.5 hours and equal to 90-140 mg / l. On average, the medicine stays inside the body for 9-11 hours (in the gastrointestinal tract of them - in the period of 15-20 minutes).
The half-life of drugs lasts 7.5 ± 0.46 hours.
About 60% of Zorex is excreted with urine, and the remainder of the medicinal substance is excreted.
Dosing and administration
To use the drug should be orally, half an hour before eating; capsule is forbidden to chew. Wash down the medication is required with ordinary water.
The sizes of portions of drugs are determined by specific situations:
- to prevent a hangover, you should take 1 capsule (volume 250 + 10 mg) of the drug after drinking - in the evening, before going to bed;
- in the treatment of alcohol withdrawal use 1-well capsule (volume 250 + 10 mg) 1-2 times a day. With the need, the daily portion can be increased to 0.75 g of unithiol, and the number of consumed per day - up to 3. The medication is used for a period of at least 3-7 days until the signs of poisoning disappear;
- in case of alcoholism, the drug is used in a complex - 1 capsule (volume 150 + 7 mg) of the substance 1-2 times a day within a 10-day cycle;
- in case of intoxication provoked by heavy metal salts or arsenic compounds, 0.3-1 g of drug per day is used per day (calculated using unithiol). This portion of the drug should be taken in 2-3 use. Therapy lasts for a period of 7-10 days.
[1]
Use Zorexa during pregnancy
There is no data regarding the use of the drug during breastfeeding or pregnancy, and therefore it is forbidden to prescribe it during the specified periods.
Contraindications
Main contraindications:
- severe hepatic diseases, at the stage of decompensation;
- renal pathologies of a severe character in the decompensation phase;
- severe intolerance associated with the components of the drug product.
Very carefully the drug is used with reduced blood pressure.
Side effects Zorexa
A medicine can cause allergy symptoms, but they only develop occasionally. Occasionally, urticaria, itching, swelling of the mucous membranes, rash on the mucous membranes and epidermis, stomatitis and itching in the genital area. Allergies are rarely developed in the form of Stevens-Johnson syndrome or Quincke's edema. With the syndrome, there is a sudden increase in temperature, a rash of a bullous or spotty-vesicular nature (on the mucous genitalia, epidermis, in the oral cavity and anal region) and anxiety.
If such signs appear, you should stop using the medicine and consult a doctor. The likelihood of the onset of allergy symptoms is higher in people with BA or in those who have a history of allergies.
With the introduction of too large portions of the development of tachycardia, nausea, dizziness, and there is pallor of the epidermis.
Overdose
Manifestations of intoxication develop in the case of exceeding the required portion tenfold or higher.
Among the signs arising in case of overdose are the following: hyperkinesis, feeling of stunnedness, lethargy or lethargy, dyspnea and the occurrence of short seizures.
In case of intoxication, gastric lavage should be performed and laxatives with activated charcoal should be given to the patient. In addition, perform symptomatic procedures, and in case of acute disorders - oxygen therapy; dextrose should also be given.
Interactions with other drugs
Unithiol is able to restore the previously weakened sensitivity of the body relative to nitroglycerin.
Pantothenate can enhance the therapeutic efficacy of SG, and in addition leads to a decrease in the toxic activity of aminoglycosides, sulfonamides, arsenic and streptomycin.
It is forbidden to combine Zorex with medicines that contain heavy metal salts.
You can not combine the drug with alkalis, because while it starts to decompose rapidly.
Storage conditions
Zorex is required to keep in a dark place, closed from the penetration of small children. Temperature readings - no higher than 25 ° C.
Shelf life
Zorex can be used in the range of 36 months from the date of manufacture of the pharmaceutical preparation.
Application for children
It can not be applied in pediatrics (up to 18 years).
Analogs
Analogues of the drug are drugs Atsizol, Protamine, Calcium thetacin, Bridan with Naloxone, and besides Naltim, Methionine, Sodium thiosulfate with Naxone, Protamine sulfate and Naloxone hydrochloride.
Reviews
Zorex gets quite a variety of reviews. For the most part, it is noted that the drug works well for a hangover, but if a person has a tendency to develop allergies, side effects are extremely common.
Manufacturer
Attention!
To simplify the perception of information, this instruction for use of the drug "Zorex" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.