Zorex

Zorex has hepatoprotective, antioxidant, complexing and detoxifying properties.

Indications Zorexa

It is used for the following disorders:

• alcohol withdrawal (to prevent the development of a hangover or to treat it);
• alcoholism in a chronic form (part of combination therapy);
• having a chronic or acute nature of intoxication, developing under the influence of inorganic or organic compounds of certain components (mercury, bismuth, chromium with zinc, arsenic, nickel, gold with copper, cadmium with antimony and cobalt);
• poisoning associated with the use of SG products.

Release form

The substance is released in capsules with a volume of 150+7 mg (10 pieces inside a box) or 250+10 mg (2 or 5 pieces inside a plate, 1-2 plates inside a box).

Pharmacodynamics

Zorex is a complexing agent and donor of thiol categories. It has detoxifying activity (also in relation to metabolic products of ethyl alcohol, arsenic compounds, and at the same time heavy metals with their compounds). Clinical tests have shown that Unitol has a hepatoprotective and antioxidant effect.

The presence of active categories of sulfhydryl nature promotes the interaction of unithiol with thiol nuclei, and along with them with the metabolic products of ethyl alcohol located inside the tissues with blood, and the formation of bonds with them (they do not have toxic properties and are excreted with urine).

When taken orally, the drug unithiol reaches the liver, where it forms irreversible physiological compounds with acetaldehyde at high speed. Due to this, alcohol (ethanol) is excreted from other tissues and organs. The drug stimulates the activation of the enzyme alcohol dehydrogenase, which potentiates oxidative processes associated with ethyl alcohol and helps the liver enzyme system to neutralize its toxic agents.

Pantothenate, which is contained in the drug, is able to potentiate the detoxifying activity of unithiol. This element is absorbed at high speed in the intestine, after which it is broken down with the release of pantothenic acid. It participates in the metabolism of fats with carbohydrates, stimulates the processes of corticosteroid formation and significantly accelerates recovery.

Pharmacokinetics

Absorption occurs at a high speed. When 1 capsule (0.25 g of unitol) is administered orally, blood Cmax values are determined after 1.5 hours and are 90-140 mg/l. The drug remains in the body for an average of 9-11 hours (in the gastrointestinal tract, of which 15-20 minutes).

The half-life of the drug is 7.5±0.46 hours.

About 60% of Zorex is excreted in the urine, and the remainder of the drug is excreted in the feces.

Dosing and administration

The medicine should be taken orally, half an hour before meals; the capsule should not be chewed. The medicine should be washed down with plain water.

The portion sizes of the drug are determined by specific situations:

• to prevent a hangover, you should take 1 capsule (volume 250+10 mg) of the medicine after drinking alcohol - in the evening, before going to bed;
• in the treatment of alcohol withdrawal, use 1 capsule (volume 250+10 mg) 1-2 times a day. If necessary, the daily dose can be increased to 0.75 g of unithiol, and the number of uses per day - up to 3. The medication is used for a period of at least 3-7 days, until the signs of poisoning disappear;
• in case of alcoholism, the medication is used in combination - 1 capsule (volume 150+7 mg) of the substance 1-2 times a day within a 10-day cycle;
• In cases of intoxication caused by heavy metal salts or arsenic compounds, 0.3-1 g of the drug is used per day (calculated according to unithiol). This dose of the drug should be taken in 2-3 doses. The therapy lasts for a period of 7-10 days.

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Use Zorexa during pregnancy

There is no data regarding the use of the drug during breastfeeding or pregnancy, and therefore it is prohibited to prescribe it during these periods.

Contraindications

Main contraindications:

• severe liver disease, at the stage of decompensation;
• severe renal pathologies in the decompensation phase;
• severe intolerance associated with the components of the medicinal product.

The drug should be used with extreme caution in cases of low blood pressure.

Side effects Zorexa

The drug may cause allergic symptoms, but they develop only occasionally. Hives, itching, swelling of the mucous membranes, rashes on the mucous membranes and epidermis, stomatitis and itching in the genital area occur occasionally. An allergy in the form of Stevens-Johnson syndrome or Quincke's edema develops occasionally. With the syndrome, there is a sudden increase in temperature, a rash of a bullous or spotty-vesicular nature appears (on the mucous membranes of the genitals, epidermis, in the oral cavity and anal area) and a feeling of malaise.

If these symptoms occur, stop using the medication and consult a doctor. People with asthma or a history of allergies are more likely to develop allergy symptoms.

When too large doses are administered, tachycardia, nausea, dizziness, and paleness of the epidermis develop.

Overdose

Signs of intoxication develop if the required dose is exceeded tenfold or more.

Signs that may occur in case of overdose include: hyperkinesis, a feeling of being stupefied, lethargic or inhibited, dyspnea and the occurrence of short-term convulsions.

In case of intoxication, gastric lavage should be performed and the patient should be given laxatives with activated carbon. In addition, symptomatic procedures are performed, and in case of acute disorders, oxygen therapy; dextrose should also be administered to the victim.

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Interactions with other drugs

Unithiol is able to restore the previously weakened sensitivity of the body to nitroglycerin.

Pantothenate can enhance the therapeutic effectiveness of SG, and also leads to a decrease in the toxic activity of aminoglycosides, sulfonamides, arsenic agents and streptomycins.

It is prohibited to combine Zorex with medications that contain heavy metal salts.

The medicine cannot be combined with alkalis, because it will begin to decompose quickly.

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Storage conditions

Zorex should be stored in a dark place, out of the reach of small children. Temperature indicators should not exceed 25°C.

Shelf life

Zorex can be used within 36 months from the date of manufacture of the pharmaceutical product.

Application for children

Not for use in pediatrics (under 18 years of age).

Analogues

Analogues of the drug are the drugs Acizol, Protamine, Tetatsin calcium, Braidan with Naloxone, and also Naltim, Methionine, Sodium thiosulfate with Naxone, Protamine sulfate and Naloxone hydrochloride.

Reviews

Zorex receives quite varied reviews. Mostly, it is noted that the drug works well for hangovers, but if a person has a tendency to develop allergies, side effects very often occur.