Venofer

The venofer has anti-anemic effect.

Indications The Venofer

It is used in such cases:

• to quickly restore the iron values inside the body for anemia, which is iron deficient in nature;
• people with intolerance with regard to tablets of iron-containing drugs (or if it is impossible to perform such a reception);
• in the presence of perforations, lesions or pathologies in the gastrointestinal tract, because of which the use of tablets is impossible.

[1],

Release form

The release of the drug is realized in the form of a solution, inside ampoules, having a volume of 2 ml. The blister plate contains 5 such ampoules. Inside the box there is 1 plate.

[2], [3]

Pharmacodynamics

The active component of the LS is a multinuclear type center containing iron atoms, and having a valence index of 3. They are surrounded by a multitude of non-covalently synthesized sucrose molecules. This complex is quite heavy, is about 43 kD, because of which the rate of its excretion through the kidneys is low enough.

The complex demonstrates high stability and does not emit iron ions. Inside the complex, iron molecules are similar to the natural element of hemoglobin - the ferritin substance.

This drug complex is required for the body to provide regulated processes for the development of iron, and in addition to its movement and preservation of the transferrin with ferritin inside the body.

[4], [5],

Pharmacokinetics

At the first injection of the drug, the peak values of iron within the blood are noted after 10 minutes.

Half-life is approximately 6 hours. The distribution volume inside the liquid spaces is rather low.

Since iron saccharate does not have stability, approximately 31 mg of iron is transported within 24 hours.

During the first 4 hours approximately 5% of iron is excreted by the kidneys. After the lapse of the first day, the parameters of the iron inside the blood return to the previous level. About 75% of sucrose is excreted from the plasma.

[6]

Dosing and administration

The drug can be administered only in / in a method - directly into a vein or through a dropper.

Before the first injection, the test dose should be injected. In this case, you must have ready-to-use resuscitation kit. In the absence of any negative symptoms within 15 minutes after this injection, the administration of the remainder of the dosage of the solution is allowed.

The size of the test portion for an adult and children weighing 14 + kg is 20 mg of iron (adult) and 1.5 mg / kg (child).

The standard adult dose is usually 5-10 ml of the substance (it should be administered 1-3 times in 7 days).

A child older than 3 years of age is given a maximum of 0.15 mg / kg at the frequency indicated for the adult.

Scheme of using drugs for intravenous injection through a dropper.

This type of injection is considered more effective and at the same time safe, because with such introduction, the risk of getting the drug under the skin decreases, as well as the likelihood of a drop in blood pressure.

Before performing the infusion, the drug is dissolved in a 0.9% NaCl solution (the proportions are 1k20). Thus, 1 ml of Venofer is dissolved in 20 ml of NaCl, 5 ml in 0.1 l, and 25 ml in 0.5 l.

The speed of the procedure is selected in this way:

• 0.1 g of iron takes 15 minutes;
• for 0.2 g - 0.5 hours;
• to introduce 0.3 g of substance - a 1.5-hour procedure;
• for the injection of 0.4 g of the drug - 2.5 hours;
• for 0.5 g of solution - 3.5 hours.

A single dose may consist of a maximum of 7 mg / kg of drug substance. Its introduction is carried out for a minimum of 3.5 hours.

The mode of intravenous administration of the medicine by the jet method.

The injection is performed by a non-diluted drug at a rate of 1 ml per minute, but the maximum amount of the drug is 10 ml per shot.

With this method of input, it is also necessary to make a test injection. For adults - 1 ml, for children - 1.5 mg of iron per kg, for a minute.

Calculation of dosage is made by the formula: body weight (kg) x Hb (g / l) x 0.24 + deposited iron (mg), where

Hb (at weight less than 35 kg) = 130 grams per liter; deposited iron = 15 mg per kg;

With a weight of more than 35 mg, Hb = 150 g / l, deposited iron = 500 mg.

If the therapeutic dose is higher than the calculated daily intake, then the drug should be taken multiple.

Improvements in blood and patient status should occur 7 to 14 days after initiation of treatment. If this did not happen, then the diagnosis should be reviewed.

Calculation of dosage after large blood loss or blood donation (donor)

If you know how much blood was lost, then the required dosage is calculated as the number of units of lost blood multiplied by 200. If Hb was lowered, then the same formula is used, provided that you do not need to replenish the iron depot.

[9], [10]

Use The Venofer during pregnancy

It is forbidden to use Venofer on the 1st trimester.

In tests conducted on animals, the negative effect of drugs on the embryo, fetus, delivery process, as well as postnatal development of the baby was not found.

Before prescribing the drug, a pregnant woman needs to carefully evaluate the likelihood of benefit and the risk of negative consequences.

Iron sugars do not enter the mother's milk. With lactation, the drug can be used only after consultation with the doctor.

Contraindications

Among the contraindications:

• other types and forms of anemia (megaloblastic or hemolytic), as well as disorders of erythropoiesis or bone marrow hypoplasia;
• the presence of intolerance with regard to drug components;
• hemochromatosis or hemosiderosis, and in addition an excess of iron within the body;
• disorders of the processes of excretion of iron from the body (thalassemia, lead intoxication, epidermal porphyria and sidero-achestic form of anemia).

[7], [8]

Side effects The Venofer

Among the most common negative signs of application of the solution: nausea, dysgeusia, a decrease in blood pressure, chills, as well as inflammation and redness at the site of injection. Single-occurrence of anaphylactoid manifestations.

Other side effects:

• metallic smack, headaches with dizziness;
• muscle spasms, diarrhea, myalgia, nausea, or vomiting;
• rash on the epidermis, hives or erythema;
• dyspnea, palpitations felt, bronchospasm, decrease in blood pressure, bradycardia, tachycardia, as well as collapse of the circulatory type;
• tides, hyperhidrosis, febrile condition and a feeling of heaviness in the sternum.

Occasionally, arthralgia, confusion or loss of consciousness, paresthesia, pruritus, increased blood pressure, pain in the back, heat feeling, edema in the joints, asthenia, severe fatigue and angioedema are noted.

If, with injection of the drug, the solution suddenly begins to flow under the skin, symptoms such as inflammation and pain in the area, tissue necrosis and staining of the epidermis can turn into brown.

Overdose

As a result of an overdose, symptoms of an acute iron overload - hemosiderosis - appear.

As therapy, the use of symptomatic agents, substances that bind chelates (deferoxamine) intravenously is indicated.

[11], [12],

Interactions with other drugs

It is not recommended to combine Venofer with iron-containing tablets, iron absorption may decrease. Treatment with this kind of drugs should be carried out no sooner than 5 days after the last injection.

[13]

Storage conditions

The drug should not be frozen and stored at a temperature above 27 degrees. Keep in original packaging.

Shelf life

Shelf life 36 months.

Use the solution is recommended immediately after opening the ampoule.

After mixing the substance with fiz. Solution it can be stored at a temperature of 18-20 degrees not more than 12 hours.

[14], [15]

Analogues

Argeferr, Ferrolek-Zdorovye, Dekstrafer, Ferinzhekt, Sufer, FerMed, Iron Saharata-iron wine, Ferrum Lek, Fermed, Likferr 100, Maltofer.

[16], [17], [18], [19], [20], [21]

Reviews

There are very few reviews about the product. The drug is effective enough in the fight against iron deficiency anemia in a hospital. Of the adverse reactions, most often complain of puffiness in the legs, nausea and dizziness, which pass some time after the injection.