Medical expert of the article
New publications
Preparations
Use of other drugs in the treatment of back pain
Last reviewed: 10.08.2022
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Nonivamide Vicoboxil (Nonivamide + Nicoboxyl)
Ointment for external use
Pharmachologic effect
Combined drug. Nonivamide is a synthetic analogue of capsaicin (a burning ingredient of hot red pepper); has an analgesic effect due to the gradual penetration of the substance into peripheral nociceptive C-fibers and A-delta nerve fibers. Nicoboxyl has a direct vasodilating effect.
The drug improves local blood flow in the skin and underlying tissues, has a warming effect. The action begins a few minutes after application and reaches a maximum in 20-30 minutes.
Indications for use
Diseases of the musculoskeletal system of traumatic and inflammatory genesis: arthritis, arthralgia, bursitis, tendovaginitis, contusion of soft tissues, stretching of the musculoskeletal system, myalgia (including caused by excessive physical exertion), osteochondrosis of the spine with radicular syndrome, neuralgia, lumbago , sciatica, sports injuries, peripheral circulatory disorders (as part of complex therapy).
Flupirtine (Flupirtine)
Capsules
Pharmachologic effect
A non-opioid analgesic of central action, a selective activator of neuronal Kr channels. Due to the indirect antagonism towards NMDA receptors that activate the descending mechanisms of pain modulation and GABAergic processes, it has analgesic, miorelaxing and neuroprotective effects.
In therapeutic concentrations it does not bind to alpha1 and alpha2-adrenoreceptors, 5HT1 and 5HT2-serotonin, dopamine, benzodiazepine, opioid, and central cholinergic receptors.
In therapeutic doses, activates the potential of independent K + channels, which leads to stabilization of the membrane potential of the nerve cell. This inhibits the activity of NMDA receptors (N-methyl-O-aspartate receptors) and as a result of blockade of neural Ca2 + channels, reduction of intracellular current of Ca2 +, inhibition of neuron excitation in response to nociceptive stimuli (analgesia). As a result of these processes, the formation of nociceptive (pain) sensitivity and the phenomenon of "wind up" ("inflating" - the growth of the neuronal response to repeated pain stimuli) is inhibited, which prevents the increase of pain, its transition to a chronic form, and with the already existing chronic pain syndrome leads to a decrease in its intensity. The modulating effect of flupirtine on the perception (pain) of pain is also established through the descending noradrenergic system.
The muscle relaxant effect is associated with blocking the transmission of excitation to motoneurons and intermediate neurons, resulting in a weakening of muscle tension.
Neuroprotective properties of the drug cause the protection of nerve structures from the toxic effect of high concentrations of intracellular Ca2 +, which is associated with its ability to cause blockade of neural Ca2 + channels and reduce the intracellular current of Ca2 +. "
Indications for use
Pain syndrome (acute and chronic): muscle spasm, malignant neoplasms, algodismenorea, headache, post traumatic pain, traumatologic / orthopedic surgeries and interventions.
Attention!
To simplify the perception of information, this instruction for use of the drug "Use of other drugs in the treatment of back pain" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.