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Thyroxin-binding globulin in the blood
Last reviewed: 11.03.2023
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The reference values (norm) of the concentration of thyroxin-binding globulin in the blood serum in adults are 13.6-27.2 mg / l; at pregnancy (more than 5 months) - 56-102 mg / l. The ability to bind TSH T 4 in adults - 100-250 g / l.
Thyroxine binding globulin binds bulk T 3 (80%) (the remaining 20% is transported albumin and prealbumin - 10%) and T 4 (75%). 10% T 4 binds albumin, 15% - prealbumin.
The test for thyroxin-binding globulin is useful for differential diagnosis of changes in T 3 and T 4 concentrations in primary thyroid diseases and as a result of the primary change in thyroxin-binding globulin.
Diseases and conditions in which the concentration of thyroxine-binding globulin in the blood serum changes
Thyroxin-binding globulin is elevated | Thyroxin-binding globulin is downgraded |
|
Infectious hepatitis Acute Renal Failure Hypothyroidism Pregnancy The use of estrogens, phenothiazines, oral contraceptives, methadone |
Severe diseases Surgical stress Insufficient protein supply Malabsorption of various etiologies Enteropathy with loss of protein Nephrotic syndrome Active acromegaly Hypofunction of the ovaries Genetic Conditionality The use of androgens, glucocorticosteroids in large doses, corticotropin, phenytoin |