Tazepam

Tazepam is classified as a psycholeptic drug based on benzodiazepine, which acts directly on the nervous system. The main ingredient of the drug is oxazepam.

Indications Tazepam

Tazepam is used to treat the following pathological conditions:

• sleep disorders;
• neurotic conditions;
• disorders of psychosomatic functions;
• disorders of the autonomic nervous system caused by the onset of menopause or cyclic disorders in women;
• reactive depressive states.

Feelings of anxiety and worry associated with household and other daily problems, and not associated with any nervous or somatic disorders, cannot be considered indications for taking Tazepam.

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Release form

Tazepam is a tablet with a thin film coating, convex on both sides, light (almost white) in color. The film that covers the tablets has a smooth, glossy appearance.

Each blister contains 25 tablets. The cardboard pack contains two blister plates.

The main ingredient of Tazepam is the axiolytic substance oxazepam.

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Pharmacodynamics

The drug belongs to a series of benzodiazepine-based medications. Tazepam has the potential to affect multiple structures of the central nervous system responsible for emotional perception - in particular, the limbic complex and hypothalamus. Tazepam helps to enhance the inhibitory effect of the cerebellum, the thalamic and hypothalamic systems, the hippocampus, and GABA-ergic nerve cells located in the cerebral cortex.

The degree of action of Tazepam depends on the modulation of GABA-ergic receptor sensitivity. The result of stimulation of benzodiazepine receptors, or GABA-a, is considered to be an increase in the transport of chloride ions into the nerve cell via the chloride channel. This process provokes increased polarization of the cell septum, and, as a consequence, a weakening of the activity of the nerve cell.

The effect of the drug is manifested in an antiphobic and slight sedative effect. Tazepam relaxes skeletal muscles, simultaneously demonstrating anticonvulsant properties.

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Pharmacokinetics

The main ingredient of the drug is well absorbed by the digestive system. Its bioavailability can be approximately 92%. When 30 mg of the main ingredient oxazepam is taken orally, the maximum level in the bloodstream is detected after 3 hours, and reaches 450 ng / ml.

The active ingredient binds to plasma proteins up to 85%. Crosses the placenta, the blood-brain barrier, and is found in breast milk.

The half-life of the drug is up to 8.2 hours.

Biological transformation (metabolism) occurs in the liver. The inactive metabolite product is excreted from the body with urine.

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Dosing and administration

There is no general treatment regimen for Tazepam, since the drug is prescribed strictly according to individual indications.

• For adult patients, Tazepam may be prescribed:
  • for psychosis, 10-30 mg up to 4 times a day;
  • for sleep disorders, 10-30 mg 60 minutes before the expected bedtime (subject to subsequent uninterrupted full 8-hour sleep).
• In elderly patients, the dosage of Tazepam should be reduced to approximately 10 mg three times a day.
• For patients with insufficient liver function, Tazepam is prescribed very carefully, starting with extremely small doses.

The total duration of treatment with the drug, including its gradual withdrawal, is 2-4 weeks. It is impossible to stop taking Tazepam abruptly, as this will cause a withdrawal syndrome.

Sometimes the doctor may make adjustments to the treatment regimen: lengthen or shorten the course of treatment, change the dosage.

Tazepam is taken orally, with a small amount of liquid. It is recommended to start treatment with small amounts of the drug, increasing the dosage if necessary.

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Use Tazepam during pregnancy

Taking Tazepam during the first three months of pregnancy may have a negative effect on the fetus and is therefore contraindicated.

Taking Tazepam during the third trimester may cause the baby to show signs of respiratory distress, low temperature and low blood pressure.

If the mother took Tazepam during pregnancy, the newborn baby may develop drug dependence, up to and including the development of withdrawal syndrome.

Studies have shown that the drug can penetrate into milk during lactation, so it is necessary to weigh all the risks and decide with your doctor whether to stop taking the drug during breastfeeding.

Contraindications

Tazepam cannot be used:

• in case of signs of high sensitivity to the ingredients of the drug;
• in case of signs of respiratory failure, regardless of etiology;
• in case of nocturnal respiratory arrest (apnea);
• in severe forms of liver or kidney diseases;
• with closed-angle glaucoma;
• in acute porphyria;
• for myasthenia;
• in case of obsessive-compulsive disorder, chronic course of psychotic disorders;
• in chronic alcoholism, intoxication with barbiturates or other medications that can depress the central nervous system;
• for the treatment of children under 6 years of age.

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Side effects Tazepam

The clinical picture of side effects depends on the treatment regimen and dosage of Tazepam.

The following side effects may occur during therapy:

• changes in the blood picture, leukopenia;
• drowsiness, lethargy, disturbances of consciousness and orientation, myasthenia, headaches;
• memory disorders, changes in libido;
• deterioration of vision, double vision;
• dyspepsia, thirst, salivation disorders;
• dysuria, enuresis;
• tremors and muscle weakness;
• loss of appetite;
• slight hypotension;
• feeling of general weakness;
• allergic reactions;
• jaundice, deterioration of liver function;
• menstrual cycle disorders in women;
• a feeling of anxiety, irritability to the point of aggression, nightmares, delusional states.

Side effects occur mainly in people who consume alcohol, as well as in elderly and mentally unstable patients.

Abrupt discontinuation of the drug may trigger the so-called withdrawal syndrome, which manifests itself in the form of tinnitus, headache, confusion, paresthesia, abdominal pain, and vomiting.

The most severe side effect may be the development of a depressive state with suicidal tendencies.

Overdose

An overdose of Tazepam may be accompanied by the following symptoms:

• fatigue, drowsiness;
• orientation disorders;
• unclear diction;
• clouding of consciousness, up to the development of a comatose state.

If you take Tazepam and alcoholic beverages at the same time, you can provoke intoxication of the body.

In case of intoxication, any methods are used to quickly remove the drug from the bloodstream. The most effective measures include gastric lavage, oral administration of sorbent drugs, and inducing a gag reflex (if the victim is conscious). Monitoring the work of all organs is mandatory: measuring the pulse, blood pressure, and monitoring breathing. If necessary, treatment is carried out according to the symptoms detected.

There is a specific antidote drug - flumazenil.

If an overdose of Tazepam was deliberate, then when providing first aid, it is necessary to make sure that the patient has not taken any additional or other drugs.

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Interactions with other drugs

The action of Tazepam is enhanced by opioids, general anesthetics, psychotropic drugs, drugs with antidepressant and antiepileptic activity, antihistamines and hypotensive drugs. Simultaneous use of opioids and Tazepam can cause euphoria and drug dependence.

The simultaneous use of Tazepam with alcohol can lead to overexcitement and aggression.

The action of Tazepam may be weakened by theophylline and caffeine.

Tazepam neutralizes the effects of levodopa and other similar drugs.

Estrogen-containing drugs may accelerate the metabolic processes after taking Tazepam.

Combined use with antiviral agents (zidovudine, ritonavir) reduces the clearance of Tazepam.

The effect of drugs that lower blood pressure is enhanced when taken simultaneously with Tazepam.

Rifampicin accelerates metabolic processes and the elimination of Tazepam from the body.

The sedative effect of Tazepam is enhanced by the action of baclofen.

The pharmacological properties of Tazepam may change under the influence of phenobarbital, carbamazepine, cimetidine, ketoconazole, erythromycin.

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Storage conditions

The drug is stored in dark, dry rooms, out of reach of children, at room temperature.

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Shelf life

The drug Tazepam can be used for 3 years.

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