Senorm

Senorm is a medical drug that belongs to the group of neuroleptics, having an antipsychotic effect.

Indications Senorma

Senorm can be used in case of:

• Schizophrenia;
• Psychoses;
• Alcohol delirium;
• Manic-depressive syndrome;
• Hypomania;
• Gilles de la Tourette syndrome;
• Behavioral disorders in children (aggression, excitability, hyperactivity);
• Uncontrollable vomiting.

Release form

On the pharmaceutical market there are Senorm in the form of:

• Tablets of one and a half or five grams, ten pieces on a plate, one hundred pieces in a box;
• Injection solution of five or fifty grams, one milliliter per ampoule. The package contains five ampoules.

Pharmacodynamics

Senorm is a derivative of butyrofen. It is a neuroleptic, exhibiting antipsychotic efficacy, as well as isolating postsynaptic dopamine receptors in such structures of the brain as mesolimbic and mesocortical. In addition, the drug also exhibits a calming and feigned efficacy. It can contribute to the occurrence of extrapyramidal disorders, but has almost no anticholinergic efficacy.

The calming effect is determined by the isolation of alpha-adrenergic receptors of the brain, the anti-anxiety effect by the isolation of dopamine D2 receptors of the vomiting center, and galactorrhea by the isolation of dopamine nerve endings of the hypothalamus.

With prolonged use, there is a modification of the endocrine status: in the anterior part of the pituitary gland, the production of prolactin “increases” and that of gonadotropic hormones decreases.

Haloperidol decanoate has a longer lasting effect in relation to Haloperidol. Due to this, stable personality modifications are reduced, delirium and visions pass, the number of obsessive ideas decreases, and interest in the outside world increases. It shows high efficiency in patients who are resistant to neuroleptic medications. It has a small activating effect.

In children with hyperactivity, it relieves increased motor activity and behavioral disorders.

The therapeutic effect of the prolonged-release form of the medication lasts up to six weeks.

Pharmacokinetics

The bioavailability of the drug is 60-70%. If Senorm is taken orally, its maximum density in the blood will reach its values in three to six hours. Senorm is almost completely (90%) bound to serum proteins.

The density in erythrocytes in relation to serum is one to twelve. In tissues the density is higher than in blood.

Metabolism occurs in the liver, the product of metabolism is not active in pharmacological terms. Excretion occurs mainly with feces (60%) or kidneys (40%). There is evidence of its penetration into breast milk. The half-life is about 24 hours (usually from 12 to 37 hours).

Dosing and administration

When taken internally:

The pill is taken half an hour before meals. Treatment begins with 1.5 - 5 mg, which should be taken two to three times a day. Then you can gradually increase the dosage to 15 mg per day until you achieve the greatest effectiveness. The daily maintenance dose is approximately 5 - 10 mg per day. The duration of treatment is two to three months.

For children from three to twelve years old:

• for psychotic disorders from 0.05 to 0.15 mg per kilogram of body weight per day;
• for non-psychotic behavioral disorders and Tourette's syndrome: 0.05 to 0.75 mg per kilogram of body weight per day.

The daily dose should be divided into two or three doses.

Injection (i.m. or i.v.):

The contents of the ampoule should be diluted with 10–15 ml of water for injection.

The recommended dose is two to five milligrams two to three times a day. After achieving a stable effect, you can switch to oral administration, increasing the daily dose by one and a half to two grams.

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Use Senorma during pregnancy

The drug can be used during the gestation period only if the probable effectiveness for the woman significantly outweighs the risk to the child.

The medicine cannot be used during breastfeeding. If Senorm is required during this period, breastfeeding should be stopped.

Contraindications

The medication should not be used in the following cases:

• Hypersensitivity to any component of the drug;
• Depression of central nervous system functionality;
• Coma;
• Depressive state;
• Hysteria;
• Parkinsonism;
• Three years of age (intramuscular administration).

Side effects Senorma

When prescribing Senorm to a patient, it is worth warning him about the following possible adverse reactions:

• Extrapyramidal disorders;
• Headache;
• Increased drowsiness;
• Increased heart rate;
• Lowering blood pressure;
• Anorexia;
• Bowel disorders;
• Nausea and vomiting;
• Liver function failure;
• Anemia;
• Agranulocytosis;
• Gynecomastia;
• Respiratory depression (IM use).

Overdose

If there is an overdose of the drug, it will probably lead to the appearance of neuroleptic reactions. The main symptom that should be paid close attention to in this case will be the "rise" in body temperature. After all, this may indicate a malignant neuroleptic syndrome. With a strong overdose, various types of impaired consciousness are likely to occur, including a comatose state and seizures.

Therapy: discontinuation of neuroleptics, use of correctors, intravenous administration of Diazepam, glucose solution, medications that belong to the nootropic group, vitamins B and C. And, in addition, therapy aimed at reducing the symptoms of overdose.

Interactions with other drugs

When used together with ethanol, medications that are opioid painkillers, barbiturates - they increase the depressant effect on the central nervous system;

Increases the effectiveness of blood pressure-lowering medications and m-anticholinergics;

Senorm, when used together with tricyclic antidepressants and MAO inhibitors, inhibits their metabolism. This results in a simultaneous increase in their sedative effect and toxicity.

Combined use with Bupropion - the epileptic threshold decreases and the likelihood of epileptic seizures increases;

With anticonvulsant medications - Sentor reduces the effectiveness of these drugs;

When Sentora is used simultaneously with Dopamine, Phenyephrine, Ephedrine and Epinephrine, the vasoconstrictive effect of the latter is reduced;

Reduces the effect of medications aimed at combating Parkinson's disease.

Decreases or increases the effect of anticoagulants;

When Sentora is used simultaneously with Bromocriptine, it may be necessary to adjust the dosage of the latter. This is explained by the fact that its effect is reduced with such use.

Psychiatric disorders may develop if Senorm is used simultaneously with Methyldopa (for example, disorientation in space, decreased thinking function may occur);

Haloperidol reduces the stimulating effect of amphetamines on the psyche, and they reduce its antipsychotic effect;

Antihistamines and anticholinergic drugs increase the m-anticholinergic effect of Senorm and reduce its antipsychotic effect;

If Carbamazapine is used together with Halpreridol for a long period of time, its density in plasma will decrease;

The likelihood of developing encephalopathy increases and etrapyramide symptoms intensify when Haloperidol interacts with Li+ medications.

Extrapyramidal reactions may also occur when Senorm interacts with Fluoxetine;

Strong tea or coffee will reduce the effect of Senorm.

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Storage conditions

Senorm should be stored in a place protected from sunlight, maintaining a temperature of 25°C. The place should be closed to children.

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Shelf life

The shelf life depends on the form of release. So:

• solution for intramuscular injection should be stored for two years;
• solutions for intravenous and intramuscular administration – three years;
• tablets - five years

Reviews

The drug can only be used as prescribed by the attending physician, who, having carefully studied the patient's medical history and weighed all possible risks, will be able to prescribe the most effective treatment regimen. The occurrence of all possible adverse reactions should also be reported to the doctor, this will help him adjust the treatment and reduce their manifestation as quickly as possible.