Raso

Razo is a medicinal antiulcer agent. Let's look at the instructions for this medication, that is, indications for use and other features of use.

The active substance of the drug is rabeprazole, its mechanism of action is based on the inhibition of a specific enzyme H+/K+-ATPase and affects the cells of the gastric mucosa. The active component works as an inhibitor of the gastric proton pump, blocking the formation of hydrochloric acid at the last stage. Depending on the dose of the drug, its substances inhibit the secretion of hydrochloric acid, regardless of the type of irritant and its nature.

Razo does not block H2 receptors, after oral administration it is completely absorbed in the gastrointestinal tract. The antisecretory effect works within an hour after taking a dose of 20 mg. The pH of the gastric environment decreases to the maximum 3-4 hours after taking the first tablet and is maintained for three days. Bioavailability is about 50% due to passage through the liver and does not increase with repeated administration.

Razo is available only with a doctor's prescription. Despite contraindications and possible side effects, rabeprazole has a significant therapeutic effect. But before using it, you should carefully read the instructions.

Indications Raso

Indications for use of Razo are based on the action of its active components. Tablets are prescribed for the treatment and prevention of diseases such as:

• Peptic ulcer of the stomach and duodenum.
• Functional dyspepsia.
• Chronic gastritis and gastrointestinal tract lesions with increased acid-forming function in the acute stage.
• Gastroesophageal reflux disease.
• Zollinger-Ellison syndrome.
• The presence of Helicobacter pylori in eradication treatment regimens (in combination with antibacterial agents).

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Release form

The form of the drug release facilitates its use, as it allows you to calculate the dosage and the number of necessary doses. Razo is released in the form of tablets of 10 and 20 mg, covered with a soluble shell that dissolves in the stomach.

The drug is released in blisters of 10 tablets each. One package of Razo contains 1-2 blisters. As a rule, this amount of medication is enough for one course of treatment or preventive therapy.

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Pharmacodynamics

Pharmacodynamics Razo is the mechanism of action of the components of the drug after oral administration. The antisecretory drug belongs to the benzimidazole group of inhibitors. It suppresses gastric secretion by inhibiting enzymes and is deactivated in an acidic pH environment. Due to this, the active substances block the channel through which hydrogen ions pass in the lumen of the glands, which reduces the level of acid secretion. Regardless of the type of stimulant, rabeprazole stops the secretion of hydrochloric acid, providing a bactericidal and cytoprotective effect.

20 mg of the substance exerts an antisecretory effect within an hour after oral administration and reaches its peak after 3-4 hours. Inhibition of hydrochloric acid secretion (basal stimulated) is observed after 24 hours after administration. The antisecretory effect occurs 3 days after the start of use. After the end of its administration, secretory activity is restored after 2-3 days. Active substances are broken down under the influence of hydrochloric acid, which is why it is advisable to use Razo in an enteric-coated form.

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Pharmacokinetics

Pharmacokinetics of Razo is information about the absorption, metabolism and distribution of the drug.

• Absorption – rabeprazole has a high absorption, which does not depend on the time of administration and food intake. After oral administration, the absolute bioavailability of the substance is 52% and does not increase with repeated use. The maximum concentration in the blood plasma is observed after 3-4 hours, while the AUC is linear.
• Distribution – the drug binds to plasma proteins, and the binding level is 97%.
• Metabolism – Razo is metabolized in the liver with the active participation of cytochrome P450 isoenzymes.
• Excretion – 90% of active substances are excreted by the kidneys as metabolites, the remaining 10% through the intestines. If the drug is taken by patients with liver failure and elderly patients, the excretion period increases by 2-3 times.

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Dosing and administration

The method of application and dosage of the pharmaceutical product are selected by the doctor, individually for each patient. The tablets are prescribed once a day, in the morning before meals, without crushing or chewing the granule. The duration of therapy is from 4 to 12 weeks. Let's consider the methods of using Razo for various diseases:

• Chronic gastritis with exacerbation of increased acid-forming function - 20 mg twice a day, course of treatment 2-3 weeks.
• Ulcerative gastroesophageal reflux or erosive disease - 20 mg once a day, the course of therapy is 4-8 weeks. If the ulcer is recurrent or complicated, then the treatment can last up to 12 months. The maintenance dose is considered to be 10 mg of rabeprazole.
• Peptic ulcer of the duodenum and stomach - 20-40 mg once a day or 10 mg twice a day. Duration of use from 2 to 4 weeks, in case of complicated disease up to 6 weeks.
• For Helicobacter pylori infection, the drug is taken in combination with antibacterial agents. The dose of rabeprazole is 20 mg twice a day for 7-8 weeks.
• Functional dyspepsia – 20 mg once or twice a day for 2-3 weeks.
• Zollinger-Ellison syndrome - 60 mg per day, with the duration of therapy selected individually and depending on the tolerability of the drug and its therapeutic effect. The maximum dosage should not exceed 120 mg per day.

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Use Raso during pregnancy

The use of Razo during pregnancy and breastfeeding is contraindicated. Since the drug has a negative impact on the well-being of the expectant mother and the development of the fetus. The use of the drug is possible in the case when the therapeutic benefit for the mother is much more important than the possible harm to the baby. In any case, the drug can be taken only after medical permission.

If urgent treatment or prevention of gastrointestinal diseases is required during pregnancy, the woman is given safe medications. As a rule, preference is given to herbal medications with minimal side effects.

Contraindications

Contraindications to the use of Razo are based on the activity of the active components and their effect on the body. Razo is prohibited in case of individual intolerance to rabeprazole and other components of the drug, including those substituted with benzimidazoles.

Patients under 14 years of age, pregnancy and lactation period are also contraindications for treatment and prevention with rabeprazole. For more accurate information about the effect of the drug on the body and the ban on its use, you can find out from your doctor.

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Side effects Raso

Side effects of Razo occur when the recommendations specified in the instructions for the medication are not followed. Most often, the drug affects the digestive system, causing flatulence, diarrhea, nausea, asthenia. In addition, a feeling of dry mouth, headaches, constipation, impaired taste sensations and increased activity of liver transaminases, increased sweating and weight gain are possible.

Drowsiness, dizziness and depression are possible when affecting the central nervous system. Dermatological reactions, i.e. skin rash, occur very rarely. Leukopenia and thrombocytopenia are often diagnosed as disorders of the hematopoietic system. Rabeprazole often causes rhinitis and pharyngitis, fever, back pain. In addition, side effects from the musculoskeletal system are observed, i.e. cramps in the calf muscles, myalgia.

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Overdose

An overdose of tablets is possible if the recommended dose is not followed, the duration of use is exceeded, or the instructions described in the instructions are not followed. Most often, side effects manifest as headache, drowsiness, nausea, vomiting, dizziness, dry mouth, and increased sweating.

Symptomatic or supportive therapy is used to eliminate them. Dialysis is not performed, as it is not effective. No specific antidote has been identified. After the body's condition has normalized, you should consult a doctor to review the dosage of the drug.

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Interactions with other drugs

Razo interaction with other drugs is possible with the permission of a doctor. The active substances do not enter into clinical interactions with other drugs metabolized by enzymes, such as Wafarin, Idiazepam, Phenytoin or Theophylline. Rabeprazole does not cause a long-term decrease in the production of hydrochloric acid, so it can be used simultaneously with drugs whose absorption is completely dependent on the pH of the stomach contents.

If Razo is used simultaneously with Ketoconazole, the concentration of the former in the blood plasma decreases by 33% and the concentration of digoxin increases by 22%. That is why, with any interaction, a correction of the doses of all drugs is required. After the end of treatment, endoscopic control is mandatory. This is necessary to exclude malignant tumors. With long-term therapy, atrophic gastritis is possible.

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Storage conditions

Storage conditions for Razo are specified in the instructions and correspond to the rules for storing any other tablet preparations. The medicine should be kept in a dry, dark place, inaccessible to children and protected from sunlight, the storage temperature should not exceed 25 °C.

If storage rules are not followed, the medicine loses its properties and is prohibited for use. Since it can cause uncontrolled side effects from many body systems.

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Shelf life

The shelf life of the drug is 18 months from the date of manufacture, subject to storage rules. After the expiration date, the tablets must be disposed of. If they have changed color or acquired an unpleasant odor, but the expiration date has not yet passed, then the drug should still be thrown away. Since such changes indicate non-compliance with storage rules and spoilage of the drug.

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