Rasol

Razol is a medicinal product for the treatment of gastrointestinal tract lesions. Let's consider the main indications for its use, contraindications, dosage and other features of the medicine.

The active component of the drug is rabeprazole, one tablet contains 10, 20 mg of this substance. Its pharmacological group is proton pump inhibitors. The drug is produced in the form of tablets and lyophilized powder for the preparation of injections and solutions.

Razol is used only as prescribed by a doctor. Compliance with the specified dosage and duration of treatment is the key to a lasting therapeutic effect and the absence of side effects.

Indications Rasol

Razol is based on the action of active components of the pharmacological agent. The medicine is prescribed for the treatment and prevention of diseases such as:

• Duodenal ulcer (active).
• Benign gastric ulcer (active).
• Symptomatic treatment of erosive or ulcerative gastroesophageal reflux disease.
• Long-term treatment of gastroesophageal reflux disease.
• Exacerbation of peptic ulcer of the stomach or duodenum with bleeding and severe erosions.
• Symptomatic treatment of gastroesophageal reflux disease (moderate to very severe).
• Zollinger-Ellison syndrome.
• Prevention of aspiration of acidic gastric contents.
• Eradication of Helicobacter pylori in patients with gastric ulcer and duodenal ulcer (in combination with antibacterial regimens).

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Release form

The drug is available in tablets (in a soluble shell), powder for injections and solutions. Depending on the indications for use, the most suitable form is selected for the patient.

As a rule, the solution is prescribed when the use of the oral form is impossible. Razol in tablets is released in a dosage of 10 and 20 mg, 10 tablets per blister. The solution is produced in glass bottles, 10 pieces per package.

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Pharmacodynamics

Pharmacodynamics Razol is based on the activity of rabeprazole. The substance belongs to the class of compounds that suppress gastric acid secretion by inhibiting the enzyme H + / K + -ATPase. Such an effect is completely dose-dependent and leads to inhibition of stimulated and basal acid secretion. After oral administration, the active component quickly leaves the plasma and gastric mucosa. The substance is quickly absorbed regardless of the dose and is concentrated in the acidic environment of gastric cells.

Razol has been studied in over 500 patients for two months. The drug does not cause cell changes and does not affect the severity of gastritis, the distribution of H. pylori, the frequency of atrophic gastritis or intestinal metaplasia. Its use is not accompanied by systemic effects on the cardiovascular, respiratory or central nervous systems. Long-term use of any form of the pharmacological agent does not affect thyroid function and hormone levels. Razol does not interact with amoxicillin and does not affect plasma concentrations of clarithromycin when used simultaneously.

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Pharmacokinetics

Pharmacokinetics of Razol is represented by the processes of absorption, metabolism, distribution and excretion. The tablets have a shell that dissolves in the stomach, since the active substance is unstable in an acidic environment. Absorption begins only after the drug passes through the stomach. Rabeprazole is absorbed quickly, the maximum concentration in the blood plasma is observed after 3-4 hours when taking a dose of 20 mg. If we compare the bioavailability of oral use and intravenous administration, then a dose of 20 mg takes 52%, while systemic metabolism, expressed to a significant extent, is not taken into account. With repeated administration, bioavailability does not increase.

The half-life is 1-1.5 hours. This process does not depend on food intake and the use of the drug, i.e. food does not affect its absorption. Binding to blood proteins is at the level of 97%. Since the active substance belongs to the proton pump inhibitors, it is metabolized by the cytochrome P450 system. A single dose of the drug does not entail changes in the urine. At the same time, about 90% of the dose is excreted in the form of two metabolites: carboxylic acid and mercapturic acid conjugate, in the form of urine. The remaining 10% is excreted with feces.

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Dosing and administration

The method of administration and dosage are prescribed individually for each patient and depend on the indications for use of the drug. The maximum dosage of the tablet form is 20 mg per day. The tablets are taken before meals, and the duration of therapy can be up to 8-12 months.

Intravenous administration is recommended in cases where oral administration is impossible. However, as soon as the oral form becomes available, intravenous injections are discontinued. To prepare injections, use a solution of 5 ml of sterile water for injection and 20 mg of rabeprazole. If the drug is used as an infusion, it is dissolved in sterile water for injection and 100 ml of infusion solution. The drug is administered slowly over 15-30 minutes. The diluted solution can be used within 4 hours after preparation. If sediment appears or a color change is observed, it should be discarded.

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Use Rasol during pregnancy

The use of Razol during pregnancy is not recommended. Such a contraindication is explained by the negative impact of the drug on the body of the mother and the unborn child. To date, there are no reliable clinical studies that would confirm the safety of Razol for this category of patients.

The use of rabeprazole is possible in cases where the expected benefit to the woman is more important than the potential risk to the health and normal development of the fetus. If the medication is prescribed after childbirth, then lactation must be stopped. The medication is not prescribed to pediatric patients.

Contraindications

Contraindications to the use of Razol are based on the action of the active components of the drug. Individual intolerance to the benzimidazole group and rabeprazole are considered an absolute contraindication.

The period of pregnancy and lactation, age of patients under 18 years, also refer to the prohibition of using the drug. Razol tablets and injections are not prescribed for patients with renal or respiratory failure.

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Side effects Rasol

Side effects of Razol occur when the rules of use specified in the instructions are not followed, the dose is exceeded or the duration of treatment is prolonged. Most often, patients suffer from headaches, diarrhea, nausea. The drug can cause dyspepsia, constipation, dry mouth, flatulence. Negative manifestations also occur from the central nervous system: dizziness, drowsiness or agitation, insomnia, taste and vision disorders. Disorders of the respiratory system are possible, i.e. dry cough, bronchitis, pharyngitis, sinusitis.

Rabeprazole may cause allergic reactions, i.e. skin rash and itching. In rare cases, the use of the drug is accompanied by painful sensations in the back, cramps in the calf muscles, fever, increased sweating, leukocytosis or weight gain. If the above side effects occur, you must stop taking the drug and seek medical help to adjust the dosage of Razol.

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Overdose

Overdose is possible when the recommended dose is exceeded or the medication is used for a long time. There is currently no information on overdose, but its symptoms look like an increase in the severity of side effects. Treatment involves symptomatic therapy, since there is no specific antidote.

The active substance of the drug binds well to plasma proteins. Dialysis is not effective. In any case, if severe symptoms of overdose appear, you should seek medical help. The doctor will review the dosage or prescribe a safer analogue.

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Interactions with other drugs

Interaction of Razol with other drugs is possible in the absence of contraindications. The active component is a proton pump inhibitor, therefore it is metabolized by enzymes included in the hepatic cytochrome P ₄₅₀ system. The drug does not enter into clinical relationships with drugs that are metabolized by enzymes of the CYP450 system (Amoxicillin, Warfarin, Theophylline, Diazepam), but causes a long-term and significant decrease in the production of hydrochloric acid. This indicates a normal interaction with drugs whose absorption is based on the pH of the gastric contents.

No relationship between taking the medicine and food has been identified. Studies have shown that the active substance has a low ability to interact with drugs. There are a number of warnings. Razol for intravenous administration is allowed to be dissolved only in physiological solution (sodium chloride) or sterile water for injection. Other solutions are contraindicated for use in infusions and injections.

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Storage conditions

Storage conditions for Razol are indicated on the packaging of the drug and in its instructions. If you purchased the tablet form of the drug, it must be stored in a place inaccessible to children, protected from direct sunlight. The storage temperature should not exceed 25 °C.

Lyophilized powder for injections and solutions should be stored in the original packaging. Razol should be protected from direct sunlight. The recommended storage temperature is 15 to 20 °C. The prepared solution should be used within four hours, otherwise it loses its medicinal properties and is subject to disposal.

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Shelf life

The shelf life of the tablet form is 18 months, and the powder for injections and solutions is stored for no more than 24 months. Do not use the medicine after the expiration date. Disposal is also necessary if the integrity of the original packaging has been compromised, the drug has changed color or acquired an odor.

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