Pharmasulin is a drug that has a potent hypoglycemic effect.
The use of Pharmasulin H is prescribed in the treatment of diabetes mellitus in situations where it is required to maintain a normal plasma sugar value with insulin. In addition, Pharmasulin H is often prescribed as a drug at the initial stage of treatment of insulin-dependent diabetes, and in addition to pregnant women suffering from diabetes mellitus.
Pharmaculin of the group H NP or H 30/70 is used for the treatment of type 1 diabetes mellitus, and also type 2 if the diet together with oral hypoglycemic drugs does not yield the desired result.
The active ingredient of Pharmasulin is insulin, which is responsible for regulating the process of glucose metabolism. In addition, this substance also affects various anti-catabolic and, together with them, anabolic processes occurring in tissues. In addition, insulin increases the formation of glycerol, and in addition fatty acids, proteins, and glycogen in muscle tissue and accelerates the absorption of amino acids. The property of insulin is the fact that it lowers the rate of disintegration of glycogen, the formation of ketone bodies, and in addition lipolysis, neoglucogenesis and the process of catabolism of amino acids together with proteins.
After subcutaneous injection of Pharmasulin H, the development of therapeutic effect on the body begins after a half an hour. The duration of the drug is 5-7 hours. The peak concentration in the blood plasma reaches 1-3 hours after the procedure.
When Pharmasulin H NP is administered, the maximum plasma insulin concentration is reached after 2-8 hours. The development of the therapeutic effect begins 1 hour after the drug administration procedure and continues for the next 18-24 hours.
In the case of the administration of Pharmasulin H 30/70, 30-60 minutes are necessary to develop a therapeutic effect. Its total duration is 14-15 hours, but in some patients it reaches even up to 24 hours. At this maximum concentration, insulin reaches 1-8.5 hours after drug administration.
Use Pharmasulin during pregnancy
Pharmaculin is usually permitted during pregnancy, but it must be taken into account that in this case it is necessary to be more careful in choosing the dosage of insulin, because a woman in this position may have a change in the need for this substance. Therefore, in case of pregnancy or at the stage of her planning, you should always consult a doctor. During this period, you need to carefully monitor the level of sugar in the blood plasma.
Pharmaculin is not allowed to be administered to patients who are hypersensitive to the drugs. It is also contraindicated in case of hypoglycemia.
With care, it is necessary to prescribe medication for patients with long-term diabetes or diabetic neuropathy, and in addition to patients who use β-blockers, because in these cases the manifestations of hypoglycemia may change or have a weak expression.
Side effects Pharmasulin
During treatment with Pharmaculin, among the side effects most often observed hypoglycemia, which can cause loss of consciousness and even death. In general, hypoglycemia develops due to the introduction of insulin in excess dosage, skipping meals, increased physical activity or alcohol consumption. To avoid this effect, it is necessary to administer the medicine strictly according to the prescriptions of the doctor, and also to follow the prescribed diet.
Due to prolonged use of the drug, hypertrophy or fatty layer atrophy under the skin at the site of injection, as well as insulin resistance syndrome, may develop. There may also be a reaction of increased sensitivity - for example, in the form of lowering blood pressure, spasm of bronchi, urticaria, and excessive sweating.
If side effects occur, you should consult a specialist, because due to certain reactions, you may need to stop using drugs, as well as special treatment.
Dosing and administration
The drug is used for IV injections or subcutaneous injections. Intramuscular injection is also permitted, but the first two options are more preferable. Schedule of drug administration, as well as dosage appoints a doctor, depending on the clinical situation of a single patient. Subcutaneously, the drug is best introduced into the thigh or the buttocks, the shoulder or abdomen. Performing injections in the same place should be a maximum of 1 rub. / Month. Carrying out the procedure, you need to ensure that the solution does not penetrate into the vascular cavity. Do not rub the injection site.
In case of an overdose of the drug, a severe form of hypoglycemia may develop. Due to a sharp change in the physical load or nutrition regime, the need for an organism in insulin may decrease, and this can lead to overdose occurring when a standard dosage is introduced. Her symptoms are loss of consciousness, the appearance of tremors, and in addition increased sweating.
As a treatment, oral glucose (sugar or sweet tea) is used. If the overdose has a severe form, you need to inject iv solution (40%) of glucose or 1 mg of glucagon substance intramuscularly. If these manipulations with a heavy degree of overdose have not had an effect, you need to enter SCS or mannitol to prevent cerebral edema.