Pharmasept

Pharmasept is a disinfection antiseptic drug.

Indications Pharmasept

The medicine is used as an antiseptic to disinfect the skin, in particular - on the hands. In addition, it can be used for lotions, various compresses or wipes, and also as a defoamer in case of pulmonary edema.

[1], [2], [3], [4], [5], [6], [7]

Release form

Alcohol solution 96% for external use. It is available in 50 or 100 ml vials.

Pharmacodynamics

With external application, the drug has a local irritant effect, as well as a tanning effect on the skin along with the mucous membranes. The active substance of the drug - ethyl alcohol - promotes the coagulation of proteins, and besides it interacts with viruses and Gram-positive, and besides them Gram-negative bacteria.

In case of internal intake of ethanol, its effect on CNS cells (most of all on the cerebral cortex) begins. Since the inhibition processes are weakened, there is an excitation characteristic of alcohol intoxication. The result can be a suppression of the functional activity of the respiratory center, and in addition a disorder in the operation of the spinal cord as well as the medulla oblongata. In the case of inhalation, systemic effects can be observed. 

[8], [9], [10]

Pharmacokinetics

Defoaming effect begins to develop after 10-15 minutes after using the drug, and the maximum drug effect the drug reaches after 1 hour.

[11], [12], [13], [14], [15], [16]

Dosing and administration

The medicine should be applied to the skin using cotton swabs or tampons. Other features of the application should be determined by the doctor, depending on which clinical picture is observed in the patient.

In case of methanol intoxication, 30% oral solution is prescribed. And besides this, an ethyl solution of 5% can be administered intravenously, in combination with a sterile saline injectable saline solution.

[30], [31], [32], [33], [34]

Use Pharmasept during pregnancy

Pregnant women are not allowed to use Pharmasept.

Contraindications

Among the contraindications: acute inflammation of the mucous membranes, as well as skin, hypersensitivity of the patient to ethyl alcohol, and in addition the age is under 14 years. In the case of using a drug to eliminate pulmonary edema, conditional contraindication is the uncoupled pain sensation in ischemic heart disease in acute form, as well as the psychomotor agitation of the patient.

[17], [18], [19], [20], [21]

Side effects Pharmasept

With topical use of drugs amongst adverse reactions of the body, irritation of mucous membranes or skin can be observed, as well as suppression of CNS functions.

[22], [23], [24], [25], [26], [27], [28], [29]

Overdose

In case of topical application, an overdose usually does not occur, but if irritation or redness appears on the area of the skin treated with the drug, you should abolish the use of medicines and wash the area with cold water.

Internal reception can cause suppression of the respiratory center function. If you use the drug orally or intravenously in a large dose, a person develops a coma. It has its own symptoms: cold-skinned, cold skin, lowering of temperature, facial hyperemia, involuntary discharge of urine or feces, vomiting, pupils narrowing (or widening if respiratory disorders have a more severe form). In addition, a frequent but weak pulse rhythm is observed, as well as a delayed respiratory rhythm and horizontal nystagmus. Occasionally, seizures, suffocation by vomit, and laryngospasm may occur rarely. Mechanical suffocation can lead to a stopping of breathing, as a result of which the functioning of the cardiovascular system may be disrupted.

In case of intoxication with ethanol after oral administration, it is necessary to induce vomiting, and then perform the procedure of gastric lavage. In the case of severe poisoning, resuscitation is required.

[35], [36], [37]

Interactions with other drugs

In the case of a combination of ethanol with nitrofurans, the toxic effect of the latter is enhanced. With the combined use of Pharmasept with oral antidiabetic drugs (aminophenolsulfonic acid derivatives), a hypoglycemic coma may occur in the patient. The use of Pharmasept with aspirin increases the possibility of developing a gastric ulcer, and when combined with thiamine, the properties of the latter become weaker.

The use of drugs along with sleeping pills can cause difficulty and suppression of the respiratory process. Neurotoxic effects of penicillins, cephalosporins, as well as fluoroquinolones in combination with Pharmasept are enhanced.

[38], [39], [40], [41], [42], [43], [44], [45]

Storage conditions

Keep the medicine in a tightly sealed package, away from sources of open flame.

[46], [47], [48]

Shelf life

Pharmasept has an unlimited period of use.

[49], [50], [51]