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Pancreatin Forte
Medical expert of the article
Last reviewed: 23.04.2024
ATC classification
Active ingredients
Pharmacological group
Pharmachologic effect
Indications Pancreatin Forte
Decreased digestion due to impaired pancreatic function that occurs in cystic fibrosis, chronic pancreatitis, pancreatectomy, dyspepsia, Remkheld syndrome, flatulence.
Problems with digestion of food that occur in conditions after the removal of the stomach and small intestine, with accelerated passage of food through the intestinal tract, when there are errors in nutrition, when the patient takes fatty, unusual or difficult digestible food, with nervousness and anxiety, stress and etc.
The occurrence of intestinal infections and chronic diseases that affect the liver and biliary tract.
Used to eliminate gases before diagnostic procedures, for example, before the X-ray examination, ultrasound, and so on.
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Release form
Pancreatin Forte is available in tablets that cover the shell, soluble in the intestinal tract. The tablets are brown or dark brown in color, round and biconvex and have a specific odor.
Tablets are packaged in ten pieces in a contour squamous packaging and placed in a cardboard box. Each bundle can have two, three or six contour packagings and an insert-instruction. Also, the tablets are packaged in a jar of dark glass or a polymer jar of sixty pieces each. Each bank is placed in a cardboard box and is supplied with a sheet with instructions.
Each tablet contains pancreatin, which contains active components - enzymes, namely amylase, lipase and protease. There are also a number of excipients: sodium carboxymethyl starch, pregelatinized starch, low molecular weight polyvinylpyrrolidone, magnesium stearate, microcrystalline cellulose.
Pharmacodynamics
The drug is a digestive enzyme that is designed to compensate for the deficiency of the secretory function of the pancreas, as well as the secretion of bile. In this case, there is an improvement in the digestion of food, a proteolytic, amylolytic and lipolytic effect is observed.
The enzymes of pancreatin, which are present in the composition of the drug, have a cleaving effect on proteins through their conversion to amino acids. The same action occurs with fats - they are converted to glycerol and fatty acids. Also, starch is also transformed - it produces dextrins and monosaccharides.
In this case, the active components of Pancreatin Forte have an analgesic effect on the pancreas and suppress its secretion.
Under the influence of the substances of the medicament, there is a more qualitative splitting of plant fiber, which leads to an improvement in digestive processes and a decrease in the formation of intestinal gases. Also, Pancreatin Forte has a choleretic effect, helps to better emulsify fats and improves the level of their absorption, leads to an increase in lipase activity.
Pharmacokinetics
To activate the enzymes of pancreatin, which are available with the drug, it is necessary to have an alkaline medium. Such a medium is in the small intestine, where the membrane of the tablets is split. The greatest effectiveness of the drug is observed in half an hour or forty-five minutes after its administration.
Enzymes can not be absorbed in the gastrointestinal tract, therefore, do not enter the systemic circulation. They undergo inactivation by hydrolysis and are digested in the intestinal tract. The small amount of Pancreatin Forte, which was not susceptible to hydrolysis, is excreted from the intestine in unchanged form along with the feces.
Dosing and administration
The medication is taken during the meal or immediately after it is finished. In this case, the tablets are not chewed and they need to be washed down with a lot of liquid: it can be water or fruit juice. The dosage of Pancreatin Forte varies depending on the age group of the patient and the severity of the impaired pancreatic function.
The initial dose of Pancreatin Forte is equal to one or two tablets. If such an amount of the drug is ineffective, then its dosage is increased by one and a half or two times. Adult patients can take a day from three to ten tablets of the drug. But with a strong violation of the secretion of the pancreas, this amount can be increased to twenty-seven tablets per day.
Children from four years old who have a history of cystic fibrosis, take the drug depending on the mass of their body. It shows the reception of one tablet for twenty-eight kilograms of the child's body weight. The maximum daily dosage for children is no more than seven tablets.
The course of therapy depends on the severity of the disease, which involves the use of the drug in the interval from several days to several months or years.
Use Pancreatin Forte during pregnancy
The action of Pancreatin Forte on a pregnant woman and the fetus is not sufficiently studied. Therefore, the use of a medicine in this period is possible only if the expected benefit is much higher than the potential risk to the fetus. The same applies to the lactation period.
Contraindications
- The presence of high sensitivity to pancreatin, which is of porcine origin.
- Hypersensitivity to other substances contained in the preparation.
- The presence of acute pancreatitis and chronic pancreatitis in the acute phase.
- Presence of intestinal obstruction.
- The patient's age is up to two years.
Side effects Pancreatin Forte
Digestive system - sometimes there are symptoms of nausea, diarrhea, constipation, discomfort in the epigastric region. Use of large doses Pancreatin Forte is able to cause in patients suffering from cystic fibrosis, strikury, which affects the ileocecal region and the ascending colon. Also, in such patients, symptoms of intestinal obstruction may occur.
Allergic manifestations - the appearance of rashes on the skin, hives, itching, rhinitis. Such reactions can be in patients who do not tolerate lactose and porcine pancreatin.
Problems with absorption of folic acid.
Appearance of perinatal irritation.
Long-term use of Pancreatin Forte and the use of large doses leads to the appearance of hyperuricemia.
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Overdose
Symptoms of drug overdose can be observed only if it is used for a long time and at high dosages. In this case, patients note the development of hyperuricosuria.
Patients with a history of cystic fibrosis and taking large doses of Pancreatin Forte receive, as side effects from overdose, the development of strictures in the ileocecal region and in the ascending colon of the intestine.
There are also symptoms of hyperuricemia.
Patients of childhood may begin to suffer from constipation.
Treatment of an overdose includes stopping the use of the medication and prescribing symptomatic therapy.
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Interactions with other drugs
At simultaneous application with a medicine antibacterial preparations, sulfonamides, antituberculous medicines are better absorbed.
Reduces the absorption of iron when taken together, especially if you use Pancreatin Forte for a long time.
The action of antacid medicines, which contain calcium carbonate or magnesium hydroxide in their composition, may lead to a decrease in the effectiveness of the medicament.
Storage conditions
Pancreatin Forte - the medicine should be kept in a dry place, inaccessible to children under 20 ° C.
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Shelf life
Pancreatin Forte is stored 24 months from the date of release.
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Manufacturer
Attention!
To simplify the perception of information, this instruction for use of the drug "Pancreatin Forte" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.