Pancreatic elastase-1 in feces

, medical expert
Last reviewed: 18.10.2021

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

The reference values (norm) of pancreatic elastase-1 in feces are more than 200 μg / g of feces.

Human pancreatic elastase-1 belongs to the family of acidic elastases. It is present in the secretion of the pancreas and feces. The enzyme does not break down when passing through the intestine. Determination of pancreatic elastase-1 in feces is a new non-invasive test for evaluating the exocrine function of the pancreas. Screening of endocrine pancreatic insufficiency is indicated when it is suspected that there is chronic pancreatitis or cystic fibrosis, as well as long-term monitoring of an already identified pancreatic insufficiency in chronic pancreatitis.

To determine the enzyme, the stool is collected for 72 hours and analyzed on the same day: if necessary, it can be frozen at -20 ° C. The results of the determination of pancreatic elastase-1 in feces are not affected by the substitution therapy with preparations of pancreatic enzymes.

If the exocrine function of the pancreas is insufficient, the content of pancreatic elastase-1 in the stool is reduced. Specificity of the test in the study of stool is 94%, sensitivity is 93%. The decrease in pancreatic elastase-1 activity in the stool is found in patients with chronic pancreatitis, pancreatic cancer, type 1 diabetes (less than 100 mcg / g in 30% of patients) and 2 (less than 100 mcg / g in 12% of patients), in children with cystic fibrosis, which reflects the insufficiency of exocrine pancreatic function in these patient groups.

trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]

Translation Disclaimer: The original language of this article is Russian. For the convenience of users of the iLive portal who do not speak Russian, this article has been translated into the current language, but has not yet been verified by a native speaker who has the necessary qualifications for this. In this regard, we warn you that the translation of this article may be incorrect, may contain lexical, syntactic and grammatical errors.

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.