Ointment for toothache

In the arsenal of local anesthetics used in dentistry, there are ointments from toothache on a gel basis, which promotes faster penetration of active substances.

Indications for the use of ointment from toothache include the relief of toothache, as well as pain in teething in children and third molars in adults, inflammatory diseases of the oral mucosa (stomatitis, gingivitis), gums and periodontium, in case of traumatic damage to the oral mucosa by dental prostheses and others.

Names of ointments for toothache: gel Kamistad (manufactured by Haupt Farma GmbH, Germany), Holisal (Jelfa SA, Poland), Kalgel (GlaxoSmithKline Pharmaceuticals, Poland).

Pharmacodynamics

The mechanism of analgesic action of the gel Kamistad provides lidocaine hydrochloride, which, due to the blocking of sodium channels of nerve fibers, does not allow pain impulses to pass through. Antiseptic effect of this ointment from toothache renders azulene extract of chemist's chamomile, also included in its composition.

Pharmacodynamics gel Kholisal is based on the analgesic and anti-inflammatory action of the derivative of salicylic acid - (2-hydroxyethyl) trimethylammonium salicyl (choline salicylate), which inactivates the enzyme of cyclooxygenase COX1 and COX2 and reduces the production of lipid mediators of prostaglandins. Also in the composition of this ointment is a broad-spectrum antiseptic chloride cetalkonium (an ammonium derivative).

And the active substances of the ointment Calgel - anesthetic lidocaine and cationic-surface antiseptic substance cetylpyridinium chloride.

Pharmacokinetics

These analgesic and antiseptic agents for topical application have a low degree of systemic absorption, manufacturers have not provided information on their pharmacokinetics.

Dosing and Administration of Ointments for Pain in the Teeth

Method of application of gels Kamistad, Kholisal and Kalgel - local: applied to the painful place with a clean finger and easily rubbed into the mucous membrane.

A single dose of Kamistad - a strip of gel 5 mm (apply after meals, up to three times a day); Holisala dosage is 1 cm for adults and 0.5 cm for children;

Calgel has the same dosage, but it can be applied up to 6 times a day.

In the instructions for these drugs, an overdose was noted in Holisal gel, which can enhance the action taken to reduce temperature and relieve pain.

Overdose of Calgel is expressed in pallor, decrease in pulse rate, difficulty breathing, and also in the occurrence of vomiting.

Clinical cases of interaction with other drugs manufacturers of these drugs have not been noted.

Storage conditions assume a temperature not exceeding + 25-30 ° C.

Shelf life of Kamistad gel is 5 years (open tube - 12 months); Kalgel - 3 years, Kholisala - 24 months.

[8], [9], [10], [11], [12], [13], [14]

Contraindications for use

Ointments for dental pain Kamistad and Holisal are not used for hypersensitivity to the components of drugs; Holysal is not used for children under 12 years old. Contraindications to the use of Calgel: heart failure (2-3 degrees) violation of the heart rhythm (bradycardia), insufficiency of the liver or kidneys, low blood pressure.

Use of ointment from toothache during pregnancy: Kamistad and Calgel are not applied; Holisal - on doctor's orders, being careful.

[1], [2], [3], [4], [5], [6], [7]

Side effects

Ointments for toothache on a gel basis can have such side effects: Kamistad and Holisal - local allergic reactions;

Kalgel - except for reactions of an allergic nature, difficulty swallowing.