Levolet

Levolet is a drug with a wide range of bactericidal and antimicrobial effects.

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Indications Levoleta

It is used to eliminate pathologies of inflammatory or infectious origin:

• tuberculosis;
• prostatitis of bacterial origin;
• infectious processes affecting the respiratory tract, kidneys and urogenital system (eg, pyelonephritis );
• Infections in the intra-abdominal area;
• lung inflammation or sinusitis;
• skin lesions of an infectious nature.

Release form

The drug is released in tablets of 0.25 or 0.5 g, 10 pieces inside a blister pack. There is 1 such blister in a pack.

Tablets of 0.75 g are also produced, 5 or 10 pieces inside a blister plate. There is 1 such plate in a box.

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Pharmacodynamics

The therapeutic compound contained in the drug is a topoisomerase 2 (DNA gyrase) blocker, as well as topoisomerase 4. This contributes to the disruption of the supercoiling process, which triggers the binding and "cross-linking" of breaks that occur in DNA. As a result, morphological transformations begin inside the cell walls, cytoplasm and membranes.

The drug is active against anaerobes (Bacteroides fragilis and Veillonella), gram-positive (staphylococci and diphtheria corynebacterium) and gram-negative (Morgan's bacterium and Escherichia coli) aerobes, as well as pathogenic bacteria with sensitivity, moderate sensitivity and resistance.

Pharmacokinetics

Absorption.

After oral administration, the drug is absorbed almost completely and quickly. Peak plasma values are noted after 1 hour after use. The bioavailability level is almost 100%.

The element levofloxacin has linear pharmacokinetic parameters within the dosage range of 50-600 mg. Food intake has little effect on the absorption of the drug.

Distribution processes.

About 30-40% of the drug is synthesized with blood serum protein. Levofloxacin accumulation when taking 0.5 g of the drug once a day is not clinically significant and can therefore be ignored. It is assumed that minor accumulation can be observed when taking 0.5 g of the drug twice a day. Stable distribution values are observed after 3 days.

Distribution processes within fluids and tissues.

Peak values of the drug inside the bronchial mucosa and bronchial epithelial secretion after oral administration of 0.5 g of the substance are 8.3 and 10.8 mcg/ml, respectively.

In the lung tissue after oral administration of 0.5 g of the drug, the peak value was about 11.3 μg/ml. It takes 4-6 hours to reach it. The substance values in the lungs were always higher than in the blood plasma.

Inside the blister fluid, the peak level of the substance (use of 0.5 g of the drug once or twice a day) was 4 and 6.7 μg/ml, respectively.

The medicine does not penetrate well into the cerebrospinal fluid.

In prostate tissue, the average drug levels (after taking 0.5 g of the drug once a day for 3 days) were 8.7; 8.2, and 2 mcg/g after 2, 6, and 24 hours, respectively. The average substance proportions in the prostate/blood plasma were 1.84.

The average values of the substance in urine after 8-12 hours after a single dose of 0.15 or 0.3 g of the drug were 44, 91, and 200 mcg/ml, respectively.

Metabolic processes.

The metabolism of the drug is extremely insignificant, among the decay products of the substance are desmethyl-levofloxacin, and also levofloxacin N-oxide. These elements make up less than 5% of the total amount of the drug excreted in the urine.

Excretion.

After oral use, the substance is excreted from the blood plasma quite slowly (half-life is about 6-8 hours). The process of excretion of the drug is mainly carried out by the kidneys (approximately 85% of the dose taken).

There is no significant difference in the pharmacokinetic properties of levofloxacin after oral or intravenous administration of the drug.

Dosing and administration

It should be noted that the size of the dose of the medicine, as well as the mode of its use, are selected taking into account the patient's condition, the severity of his pathology, and also the sensitivity of pathogenic microbes to the active elements of the medicine. On average, the course of therapy with Levolet lasts a maximum of 2 weeks.

The drug should be taken in a dosage of 0.25 or 0.5 g before meals or in between, washed down with plain water (tablets should not be chewed). Like other antibiotics, the drug Levolet must be taken for at least 48 hours after laboratory confirmation of the destruction of pathogenic bacteria and stabilization of normal temperature.

For therapy in people with kidney problems, it is necessary to change the dosage of the drug.

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Use Levoleta during pregnancy

Levolet should not be prescribed to pregnant or lactating women.

Contraindications

Among the contraindications:

• the presence of high sensitivity to quinolones, and in addition to medicinal elements;
• epileptic seizures;
• lesions affecting tendons.

The drug is prescribed with extreme caution to elderly patients and people with a deficiency of the G6PD element in the body.

Side effects Levoleta

The drug can provoke the development of the following side effects:

• disorders of hematopoietic function: anemia or leukopenia;
• digestive disorders: diarrhea, loss of appetite, abdominal pain, nausea, and dysbacteriosis;
• problems with the functioning of the cardiovascular system: tachycardia, vascular collapse;
• disorders of the nervous system: dizziness, depression, convulsions and paresthesia, headaches, and also a feeling of drowsiness;
• others: deterioration of renal function, hypoglycemia, rhabdomyolysis, exacerbation of porphyria, as well as taste, vision and olfactory disorders and hepatitis;
• problems with muscle and skeletal function: rupture in the tendon area, tremors in the upper limbs and pain in the muscles.

In addition, the use of drugs can lead to the appearance of allergy symptoms - such as rash, itching, reddening of the epidermis, as well as phlebitis, anaphylaxis, vasculitis, fever and TEN. This also includes urticaria, allergic pneumonitis, Stevens-Johnson syndrome and others.

Overdose

In case of poisoning with a drug, the victim may experience symptoms such as convulsions, nausea, dizziness, a feeling of confusion, prolongation of the QT interval, and damage to the mucous membranes of the gastrointestinal tract.

Interactions with other drugs

The effectiveness of the therapeutic effect of the drug is reduced by antacids, as well as by drugs that contain aluminum, iron salts, sucralfate and magnesium.

It is prohibited to combine Levolet with theophylline, cimetidine, NSAIDs, GCS and medications that affect the processes of tubular secretion.

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Storage conditions

Levolet must be kept in a dark place, out of the reach of small children. It is prohibited to freeze the medicine. Temperature values are a maximum of 25°C.

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Shelf life

Levolet can be used for 2 years from the date of release of the therapeutic agent.

Application for children

The medicine should not be used by people under 18 years of age.

Analogues

Analogues of the drug are Glevo, Flexid, Ivacin with Leflobact and Levoflox, and in addition Levofloxabol, Remedia, Ecolevid and OD Levox with Tanflomed.

Reviews

Levolet receives quite polar reviews regarding its medicinal effectiveness. Customers' opinions are divided - some say that the medicine works quite well and is inexpensive, but others note that it has quite a lot of side effects, which is why the benefits of the medicine are seriously questioned.