Lanzap

Lanzap is a proton pump inhibitor.

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Indications Lanzapa

It is indicated for the treatment of duodenal ulcers and gastric ulcers, as well as GERD and gastrinoma. It is also used to destroy the Helicobacter pylori bacteria (in combination with antibiotics).

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Release form

Available in capsules of 10 pieces on 1 blister. The pack contains 2 blister plates.

Pharmacodynamics

Lanzap is classified as an antisecretory, antiulcer drug. It inhibits the activity of H ⁺ K ⁺ ATPase inside the parietal cells of the gastric mucosa. This allows the drug to suppress the final stage of acid formation in gastric juice and at the same time reduce its amount and acidity level. This reduces the negative effect of gastric juice on the mucosa. The strength of suppression depends on the dosage and the duration of the therapeutic course. A single dose of 30 mg allows you to suppress the production of hydrochloric acid by 80-97%.

Pharmacokinetics

Lansoprazole is a labile acid contained in the drug in granules with an intestinally soluble surface. The substance is rapidly absorbed in the intestine. Peak plasma levels are 0.75-1.15 mg/l and are reached in 1.5-2.2 hours.

The drug is excreted with urine and bile. The half-life is 1.5 hours. This indicator may increase in people suffering from severe liver dysfunction, as well as in the elderly. In case of renal failure, there are almost no changes in the absorption rates of lansoprazole. It is synthesized with plasma protein by 98%.

Dosing and administration

The capsules should be taken whole, without chewing or crushing. Wash down with water. Take usually once a day – in the morning or in the evening (in both cases before meals).

For duodenal ulcers, it is necessary to take 30 mg twice a day for a period of 2-4 weeks.

For stomach ulcers, take 30 mg twice a day for 2-8 weeks.

For GERD, 30 mg of the drug is taken twice a day for 1-2 months. After this period, maintenance treatment begins: taking 30 mg per day for up to 1 year.

For gastrinoma, the initial dosage is 30 mg three times a day. The dose is then adjusted based on the basal acid secretion in the stomach:

• less than 10 mEq/hour for people who do not have a history of gastric surgery;
• less than 5 mEq/hour in people who underwent such interventions.

Daily doses within 120-180 mg should be administered twice a day (morning and evening).

The destruction of Helicobacter pylori bacteria can be carried out according to the schemes indicated below.

"Triple" treatment:

• a dose of 30 mg twice a day, in combination with metronidazole at a rate of 500 mg twice a day (or with tinidazole, also 500 mg) and clarithromycin: 500 mg twice a day;
• dosage of 30 mg twice daily in combination with twice daily intake of 500 mg clarithromycin, as well as twice daily intake of 1000 mg amoxicillin.

"Quadro" treatment, which helps to achieve results in people who have not been helped by the "triple" treatment scheme:

• 30 mg twice daily in combination with bismuth medications (e.g. bismuth subcitrate): 120 mg four times daily (dosage calculated as bismuth oxide). Also with tetracycline: 500 mg four times daily and metronidazole: 500 mg three times daily (or tinidazole, 500 mg three times daily).

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Use Lanzapa during pregnancy

It should not be prescribed to pregnant women. Breastfeeding should be discontinued during treatment.

Contraindications

Contraindications include: intolerance to the components of the drug, as well as childhood.

Side effects Lanzapa

In general, the drug is well tolerated, but in case of prolonged use, side effects may develop:

• digestive system: abdominal pain, diarrhea and nausea, occasionally constipation develops;
• nervous system organs: headaches, in rare cases fatigue, drowsiness and dizziness may occur;
• skin manifestations: rash, erythema multiforme, and urticaria;
• Others: dryness of the oral mucosa occasionally develops.

Interactions with other drugs

Since the drug is metabolized in the liver using the P450 hemoprotein system, caution should be exercised when combined with phenytoin, prednisolone and diazepam, as well as theophylline, propranolol and warfarin (Lanzap can reduce the elimination of these drugs, which requires a reduction in their dosages).

Antacid medications containing magnesium and aluminum hydroxide may be taken at least 2 hours after taking Lanzap.

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Storage conditions

The medicine should be kept in a place out of reach of children, as well as away from the sun and moisture. The temperature indicator is a maximum of 25°C.

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Shelf life

Lanzap is approved for use for 2 years from the date of release of the drug.