Ibufen

Ibufen, is widely used in pediatrics. It is designed to relieve an unpleasant pain syndrome, and does not pose any danger to the growing up organism. 

[1], [2], [3], [4]

Indications Ibufen

Indications for use Ibufen - a pain relief syndrome in children, including during the eruption of teeth. It is effective for colds, acute respiratory viral infections and influenza. In addition, it is used for angina, pharyngitis, toothache and painful teething.

Ibupen allows you to get rid of a headache of various origins, including migraines. He is able to eliminate childhood infections, which are accompanied by a fever.

Medication is widely used in pediatric practice. It can be used in complex therapy to eliminate respiratory viruses. Assign a remedy for postvaccinal reactions. All this testifies that the spectrum of its action is wide. Despite the great spread, it is possible to apply Ibufen exclusively with the approval of a pediatrician. Self-medication in this case is inappropriate and can lead to serious complications. 

[5], [6], [7]

Release form

Form release - suspension, intended for oral use. Ibufen is produced in 100 ml glass bottles. The package contains one bottle complete with a measuring device. This will make it easier to take the medicine and will allow you to exactly use the necessary dose.

In 5 ml of the drug contains 100 mg of the main component of ibuprofen. There are auxiliary components, namely sucrose. It allows you to give the drug a more pleasant taste.

There are no other forms of release, Ibuphen is supplied exclusively in the form of a suspension. Thus, it is possible to achieve a rapid effect. Thanks to the active component, relief after taking the remedy comes almost immediately. But much depends on the condition of the child and the disease. Pain syndrome is stopped within a few minutes. Especially it is possible to observe this picture in the presence of headache and dental pain. Ibufen is an effective children's remedy, whose action is aimed at eliminating catarrhal diseases and pain of varying intensity. 

[8], [9], [10], [11]

Pharmacodynamics

Pharmacodynamics Ibuphen is the main component of ibuprofen. It belongs to the group of non-narcotic analgesics. It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of its action is associated with the inhibition of the synthesis of prostaglandins. This leads to a decrease in the intensity of the inflammatory process. As a consequence, the body temperature is normalized, the generation of pain impulses along the nervous structures is reduced.

The effect on the synthesis of prostaglandins medication is due to the inhibition of the enzyme cyclooxygenase. It plays an important role in the metabolism of arachidonic acid and the formation of prostaglandins.

After using the medication, the antipyretic effect develops within 30 minutes and reaches its maximum after 3 hours. This allows you to keep the effect for a long time. Ibupen is perfectly absorbed in the gastrointestinal tract, without causing pronounced side effects. 

[12], [13], [14], [15], [16], [17], [18], [19], [20]

Pharmacokinetics

Pharmacokinetics Ibufen - absorption occurs in the gastrointestinal tract. The maximum amount of the drug in the blood plasma is observed after 1-2 hours after administration. The active component is characterized by a high degree of association with plasma proteins.

The drug is metabolized in the liver, it is excreted mainly by the kidneys. And this happens both in an unchanged form, and in the form of metabolites. The elimination half-life is 2 hours. Completely eliminated from the body of the drug during the day. Cumulation of the active component in the body is not noted.

Ibufen has antipyretic, anti-inflammatory and analgesic effects. Therefore, it is used both to eliminate pain syndromes and colds. Dangers to the child's body, he does not carry, you can use it freely. The only thing, it is desirable to get advice from a therapist. Limitations on the child's age Ibufen has not. 

[21], [22], [23], [24], [25], [26], [27], [28], [29], [30]

Dosing and administration

Dosage and administration - the drug is intended for oral use. Before using the product, it must be shaken thoroughly in a vial until a uniform mixture is obtained. To reduce the occurrence of possible side effects, the drug should be taken after a meal. It should not be diluted with water, but it is quite possible to drink it. The dose of the drug is prescribed by the attending physician. The duration of treatment depends on the condition of a person and is selected individually.

Children with pain syndrome and hyperthermia are prescribed 20-30 30 mg / kg of body weight per day. The daily dose should be divided into 3-4 doses. There is an interval of 4 hours between uses. After the vaccination, the child usually recommends taking 2.5 ml of the drug once. If necessary, the effect is repeated after 6 hours. The total dose should not exceed 5 ml.

If the patient's condition does not improve within 3 days, you should contact a specialist. In this case, a repeated diagnosis of the disease and adjustment of the treatment regimen of the drug Ibufen. 

[37], [38], [39], [40], [41], [42], [43], [44], [45]

Use Ibufen during pregnancy

Use during pregnancy should be discontinued in the first and second trimester. The fact is that there is no data on admission during this period, no relevant studies have been carried out. Strictly contraindicated use in the last months of pregnancy.

If necessary, use the product during lactation, it is necessary to consult with a specialist. Most likely, breastfeeding for a while will be discontinued.

For the first time in pregnancy, taking any medication carries a potential danger. There is always a risk of complications. In this case, we mean the possibility of developing pathologies in the baby and aborting the pregnancy. It is always necessary to compare the positive effect for the mother with possible negative consequences for the baby. The use of a medication is advisable, if the first criterion is several times higher than the latter. Otherwise, Ibufen carries a special risk and can provoke any negative consequences. 

Contraindications

Contraindications to the use of Ibuphen carry an extensive list. Do not use medicines for people with increased hypersensitivity to its main components. The drug is not assigned to people who have a history of "aspirin triad." This can lead to the development of bronchospasm, urticaria and allergic rhinitis. Patients with a violation of malabsorption of glucose-galactose and deficiency of glucose-6-phosphate dehydrogenase use the agent also can not.

People suffering from peptic ulcers of the stomach and duodenum, hemorrhagic diathesis, a tendency to bleeding, a violation of blood coagulability, severe impairment of liver and / or kidney function, and severe heart failure are at risk.
Such therapy is contraindicated for people who are treated with non-narcotic analgesics, including selective non-narcotic analgesics. Naturally, there are restrictions in women in the third trimester of pregnancy. The medication is not used by patients younger than 6 months. With caution the agent is used for ulcerative colitis, Crohn's disease, liver, kidney and heart diseases. Ibupen can influence the ability to concentrate attention and manage complex mechanisms. 

[31], [32]

Side effects Ibufen

Side effects of Ibufen are diverse and are able to manifest themselves in many organs and systems. Usually, the remedy is well tolerated by patients, but in isolated cases, all the same, there are negative reactions from the body.

The gastrointestinal tract and liver manifest themselves in the form of nausea, vomiting, indigestion, pain in the epigastric region. It is not excluded flatulence, gastritis. Possible development of peptic ulcer of the stomach, gastrointestinal hemorrhage, impaired renal function.

From the side of the cardiovascular system, increased blood pressure, anemia, thrombocytopenia, agranulocytosis, pancytopenia, and leukopenia are not ruled out.

Central nervous system: headache, disturbed sleep and wakefulness, emotional lability, tinnitus, irritability and fatigue.

On the part of the urinary system, hypernatremia, edema, renal dysfunction. Naturally, allergic reactions can occur. They manifest themselves in the form of skin rash, itching, Stevens-Johnson syndrome, hives, anaphylactic shock and bronchospasm. Ibupen has not a small list of side effects, but they are extremely rare. 

[33], [34], [35], [36],

Overdose

Overdose is possible with the use of overestimated doses of the drug. It manifests itself in the form of nausea, vomiting, headache, pain in the epigastric region, dizziness, drowsiness and lowering blood pressure. In this case, it is worth doing an immediate gastric lavage and stop taking the drug.

If you continue to use the drug in excessive doses, over time, develops metabolic acidosis, impaired renal and hepatic function, loss of consciousness, convulsions and respiratory arrest are not ruled out. Patients suffering from bronchial asthma may notice the development of bronchospasm. Particularly sensitive to increasing doses - babies under 5 years.

There is no specific antidote. When there are symptoms of an overdose, a person is washed with a stomach and given an intake of enterosorbents. But only in the event that after the use has passed no more than an hour. Symptomatic therapy also takes place. The intake of Ibufen in the prescribed doses and in the absence of contraindications to the appearance of negative reactions will not result. 

[46], [47], [48], [49], [50], [51]

Interactions with other drugs

The interaction of Ibuphen with other drugs is excluded in some cases, especially if medicines from the same group are used simultaneously. Thus, its combination with non-steroidal anti-inflammatory drugs is prohibited.

The drug reduces the effectiveness of antihypertensive drugs and diuretics. A similar situation develops with means that increase blood pressure. With the combined use of the drug with diuretics and cyclosporine, the risk of developing nephrotoxic action is increased.

The medication enhances the therapeutic effect of anticoagulants when applied simultaneously. Combine it with Methotrexate is prohibited, significantly increases the toxicity of the latter. Interaction with glucocorticosteroids increases the risk of side effects from the gastrointestinal tract. Ibupen, together with Zidovudine, may lead to an increase in bleeding time.
 

[52], [53], [54]

Storage conditions

Ibufen requires an optimal temperature and normal humidity. The drug should be stored in a dry place, where there is no light, including direct sunlight. The recommended temperature varies between 15-25 degrees Celsius.

It is advisable to place the medicine in the first aid kit. Children should not have access to the drug, in spite of the fact that it is not contraindicated to them. There is a risk of harm to one's own organism. Excessive use of the drug leads to a serious overdose.

An important role is played by the appearance of the medication. Before each use it must be shaken. If special changes were noticed during this process, it is necessary to refuse reception. A different color, smell, and taste indicate incorrect storage conditions. It is worth to get rid of a medicine. Ibufen does not need to be placed in the refrigerator. Long-term storage leads to a decrease in pharmacological action. 

[55], [56]

Shelf life

Shelf life of the drug is 3 years. But here there is a small nuance. After opening the bottle, you can use the medicine for 6 months. After the expiration of the prescribed period, the pharmacological action does not appear. At best, the remedy will not have a positive effect, at worst will cause unpleasant side effects. After the expiry of the storage period, it is prohibited to use medicament.

In order for the device to serve for a given period, it needs to create optimal conditions. They are included in the observance of temperature and humidity. Dampness, cold and heat will spoil the medicine. It is advisable to place it in a dry, warm place, with a temperature not higher than 15-25 degrees.

Children should not have access to a medication. They can easily damage the bottle and hurt yourself. You can put the drug in the medicine cabinet. Any external and taste changes indicate improper storage. In this case, Ibufen is better to throw. 

[57], [58], [59], [60]