Ibufen Junior

The drug Ibufen Junior is a non-steroidal anti-inflammatory drug, the active substance of which is ibuprofen, which is included as a therapeutically active component in such generic drugs as Ibuprex, Ibuprof, Ibusan, Ipren, Nurofen, Brufen, etc.

[ 1 ]

Indications Ibufen Junior

The anti-inflammatory, antipyretic and analgesic drug Ibufen Junior is recommended for use in pediatrics not only in the complex treatment of acute respiratory viral infections and influenza, but also in case of possible reactions that often occur after vaccination of children, as well as to relieve pain of various etiologies, including painful teething.

[ 2 ], [ 3 ], [ 4 ]

Release form

Ibufen Junior is available in the form of a suspension for internal use (in 100 ml bottles); the package contains a dosing spoon or a syringe-shaped dispenser.

Pharmacodynamics

The active substance ibuprofen determines the pharmacodynamics of Ibufen Junior, which is associated with the ability of ibuprofen to reduce the activity of the enzyme cyclooxygenase, which helps to reduce the intensity of the synthesis of prostaglandins - lipid mediators of the neurohumoral system of the body present in all tissues and organs. Due to this, the body temperature decreases during inflammatory processes, the inflammatory reactions themselves are neutralized, and pain syndromes disappear.

[ 5 ], [ 6 ], [ 7 ], [ 8 ], [ 9 ], [ 10 ]

Pharmacokinetics

After oral administration of Ibufen Junior, ibuprofen is absorbed in the gastrointestinal tract and binds to blood proteins; in blood plasma, the highest concentration is reached approximately 60-90 minutes after administration. At the same time, a decrease in elevated temperature begins within half an hour after taking Ibufen Junior, with complete normalization of temperature after three hours.

Biochemical transformation of the drug occurs in the liver; a significant portion of metabolites and a certain amount of unchanged ibuprofen are excreted by the kidneys (the excretion time of half the dose taken is almost two hours). Ibufen Junior does not accumulate in the body and is completely excreted within 24 hours.

[ 11 ], [ 12 ], [ 13 ], [ 14 ], [ 15 ], [ 16 ]

Dosing and administration

The drug is taken orally, after meals (can be washed down with water). The dosage is determined by the doctor on an individual basis - depending on the diagnosis, age and body weight of the child. Children 3-12 months - 2.5 ml 3 times a day; 1-3 years - 5 ml (three times a day); 4-6 years - 7.5 ml; 7-9 years - 10 ml; 10-12 years (30-40 kg) - 15 ml 3 times a day. The drug can be taken for three days.

In case of pain and high temperature in children, the daily dose is determined at the rate of 20-30 mg per kilogram of body weight and is taken 3-4 times, but not earlier than 4 hours after the next dose. After vaccination, 2.5 ml of Ibufen Junior suspension is prescribed - in one dose.

[ 21 ], [ 22 ], [ 23 ]

Use Ibufen Junior during pregnancy

The use of Ibufen Junior during pregnancy in the first and second trimesters is not recommended (there is no information regarding its safety for the mother and fetus). And the use of this drug in the third trimester of pregnancy is strictly prohibited.

Contraindications

First of all, contraindications for use include individual hypersensitivity to the active substance of the drug (ibuprofen), as well as to all non-steroidal anti-inflammatory drugs.

Ibufen Junior is not used in case of allergy to aspirin, ulcerative lesions of the stomach and intestines, decreased blood clotting, liver and kidney disorders, high blood pressure and heart failure. This drug should not be taken before surgery.

[ 17 ], [ 18 ]

Side effects Ibufen Junior

Although this drug is generally well tolerated by patients, Ibuprofen Junior may have the following side effects: headache and dizziness, sleep disturbances and irritability, nausea and vomiting, digestive and stool disorders, increased blood pressure and heart rhythm disturbances, etc.

In case of an allergic reaction to this drug, itching of the skin and rash, bronchospasm, Quincke's edema and anaphylactic shock may occur.

[ 19 ], [ 20 ]

Overdose

Overdose of this drug is accompanied by headache, nausea, vomiting, stomach pain, increased drowsiness, decreased blood pressure and heart rhythm disturbances. With a significant level of overdose, there may be: a shift in the acid-base balance of the body towards increased acidity, convulsions, partial dysfunction of the kidneys and liver, fainting, respiratory arrest. In case of overdose, it is necessary to wash out the stomach and take activated charcoal.

[ 24 ], [ 25 ], [ 26 ], [ 27 ], [ 28 ], [ 29 ]

Interactions with other drugs

Ibuprofen Junior should not be taken simultaneously with other non-steroidal anti-inflammatory drugs.

In addition, Ibufen Junior reduces the effectiveness of diuretics and drugs for the treatment of hypertension and arterial hypotension. When used simultaneously with anticoagulant drugs, Ibufen Junior enhances their therapeutic effect. It can increase the likelihood of side effects of corticosteroid drugs.

[ 30 ], [ 31 ], [ 32 ]

Storage conditions

Storage conditions: dry place, protected from sunlight, temperature +15-25°С.

[ 33 ], [ 34 ], [ 35 ]

Shelf life

The shelf life of an unopened bottle is three years, and after opening the bottle - no more than six months.

[ 36 ], [ 37 ]